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Necla y poster

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Necla YCEL

Pomegranate peel is a rich source of ellagic acid, which has many health benefits. Conventionally, ellagic acid is purified from plant extracts through recrystallization and liquid-liquid extraction, which are inefficient and use large amounts of solvent. This project aims to develop a more efficient purification method using molecularly imprinted polymers. Molecularly imprinted polymers are synthesized to create cavities that selectively bind the target molecule, in this case ellagic acid. The process involves mixing the ellagic acid template with functional monomers and a cross-linker, then polymerizing and removing the template to leave imprinted cavities for isolating pure ellagic acid from pomegranate peel.

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Pomegranate [Punica granatum L. (Punicaceae)] peel is a rich source of hydrolysable tannin belonging to ellagitannins. It is therefore an inexpensive and abundant source of elagic acid. Ellagic acid has the benefit of being anti- inflammatory, anti-allergy, anti-cancer, reducing microbial growth, and a protective effect against testicular toxicity. Conventionally, puri鍖cation of EA from crude plant extracts is performed by recrystallization and Liquidliquid extraction (LLE), which are low-cost and easy- to-handle strategies yet are often tedious, low-ef鍖cient, and accompanied with consumption of a large amount of organic solvent. High-speed countercurrent chromatography is a good alternative to the traditional methods but its application is not yet common for large-scale industrial production. Although solid phase extraction (SPE) tactics have been reported for ellagic acid (EA) puri鍖cation, the adopted extraction media are usually lack of speci鍖city and selectivity, leading to poor puri鍖cation ef鍖ciency. In this project, a new purification method which is molecular imprinting polymer will be used to obtain pure ellagic acid from pomegranate peel. A Molecularly Imprinted Polymer (MIP) is a polymer that has been processed using the molecular imprinting technique which leaves cavities in polymer matrix with affinity to a chosen "template" molecule. INTRODUCTION OBJECTIVES Department of Genetics and Bioengineering, Istanbul Bilgi University Necla YCEL, Prof. Hatice GLEN SYNTHESIS OF MOLECULARLY IMPRINTED POLYMER FOR THE ISOLATION OF PURE ELLAGIC ACID FROM POMEGRANATE PEEL STAGES OF THE PROJECT METHOD ACKNOWLEDGEMENTS necla.yucel@bilgiedu.net necla-ycl@hotmail.com Figure 1: Benefits of Ellagic Acid Figure 2: Ellagic Acid in the Pomegranate Peel In this project, molecularly imprinted polymer will be synthesized to obtain pure ellagic acid molecule from pomegranate peel. The process of preparing a molecularly imprinted material involves three main steps: (a) the mixing or binding of one or several (functional) monomers with the template molecule in a suitable solvent or dispersion liquid; (b) the polymerization of monomers in the presence of a cross-linker to prepare a polymer network in which the functional monomers become fixed around the template and (c) removal of the template from the solid. I thank you, Assist. Prof. P脹nar AKIR HATIR who is academician at Arel University, as she became my guide throughout this project. Pharkphoom Panichayupakaranant, Atcharaporn Itsuriya1 , and Anusak Sirikatitham et al. 2010, Preparation method and stability of ellagic acid- rich pomegranate fruit peel extract, NCBI Cornelus F. van Nostrum et al. 2005, Molecular imprinting: A new tool for drug innovation, pg.120, Elsevier REFERENCES ELLAGIC ACID Figure 3: Synthesize steps of Molecular Imprinting Polymer Define the Problem & Research Objectives Develop the Research Plan Materials To Be Used Were Provided Molecularly Imprinted Polymer Synthesis Binding Step Isolation of Ellagic Acid from Pomegranate Peel Analyze Data Write Report Template Molecule

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Necla y poster

  • 1. Pomegranate [Punica granatum L. (Punicaceae)] peel is a rich source of hydrolysable tannin belonging to ellagitannins. It is therefore an inexpensive and abundant source of elagic acid. Ellagic acid has the benefit of being anti- inflammatory, anti-allergy, anti-cancer, reducing microbial growth, and a protective effect against testicular toxicity. Conventionally, puri鍖cation of EA from crude plant extracts is performed by recrystallization and Liquidliquid extraction (LLE), which are low-cost and easy- to-handle strategies yet are often tedious, low-ef鍖cient, and accompanied with consumption of a large amount of organic solvent. High-speed countercurrent chromatography is a good alternative to the traditional methods but its application is not yet common for large-scale industrial production. Although solid phase extraction (SPE) tactics have been reported for ellagic acid (EA) puri鍖cation, the adopted extraction media are usually lack of speci鍖city and selectivity, leading to poor puri鍖cation ef鍖ciency. In this project, a new purification method which is molecular imprinting polymer will be used to obtain pure ellagic acid from pomegranate peel. A Molecularly Imprinted Polymer (MIP) is a polymer that has been processed using the molecular imprinting technique which leaves cavities in polymer matrix with affinity to a chosen "template" molecule. INTRODUCTION OBJECTIVES Department of Genetics and Bioengineering, Istanbul Bilgi University Necla YCEL, Prof. Hatice GLEN SYNTHESIS OF MOLECULARLY IMPRINTED POLYMER FOR THE ISOLATION OF PURE ELLAGIC ACID FROM POMEGRANATE PEEL STAGES OF THE PROJECT METHOD ACKNOWLEDGEMENTS necla.yucel@bilgiedu.net necla-ycl@hotmail.com Figure 1: Benefits of Ellagic Acid Figure 2: Ellagic Acid in the Pomegranate Peel In this project, molecularly imprinted polymer will be synthesized to obtain pure ellagic acid molecule from pomegranate peel. The process of preparing a molecularly imprinted material involves three main steps: (a) the mixing or binding of one or several (functional) monomers with the template molecule in a suitable solvent or dispersion liquid; (b) the polymerization of monomers in the presence of a cross-linker to prepare a polymer network in which the functional monomers become fixed around the template and (c) removal of the template from the solid. I thank you, Assist. Prof. P脹nar AKIR HATIR who is academician at Arel University, as she became my guide throughout this project. Pharkphoom Panichayupakaranant, Atcharaporn Itsuriya1 , and Anusak Sirikatitham et al. 2010, Preparation method and stability of ellagic acid- rich pomegranate fruit peel extract, NCBI Cornelus F. van Nostrum et al. 2005, Molecular imprinting: A new tool for drug innovation, pg.120, Elsevier REFERENCES ELLAGIC ACID Figure 3: Synthesize steps of Molecular Imprinting Polymer Define the Problem & Research Objectives Develop the Research Plan Materials To Be Used Were Provided Molecularly Imprinted Polymer Synthesis Binding Step Isolation of Ellagic Acid from Pomegranate Peel Analyze Data Write Report Template Molecule