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pharmacokinetics ccd antisnake venom ask antidiabetics em cmv anaesthesia copd ibs chronic idiopathic constipation antimalarial contraception dmpa oc pills stewardship drug resistance bedaquiline mdr tb tuberculosis strophanthin digoxin aconitine langendorff pd istradefyline safinamide duodopa community acquired pneumonia cap sacubitril nesiritide ccf levosimendan organophosphorus opp eclampsia antiseptics snakebite