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immunology factors which induce tolerance autoimmune esopageal cancer esophagitis mallory weis tear esophagus barret's esophagus pathophysiology emphysema lung disorders bronchitis chronic obstructive pulmonary disease obstructive lung disease copd inflammation cytokines chemical mediators chemokines who immunophenotyping malignancy tumors autoantibodies autoimmunity b & t cell tolerance tolerance immunologic tolerance major histocompatibility complex basic immunology concepts antigen presentation mhc immunoglobulins antibodies antigens enterocolitis ischemic colitis mesenteric ischemia colonic ischemia principles of shock pathophysiology of shock consequences of shock types of shock shock hematology