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pharmacovigilance case adverse drug reaction drugs adverse drug event thyroid hormone mechanism hypokalemia chloroquine allium sativum analgesia pain models ajoene allicin garlic halothane drug induced hepatitis hepatitis pharmacodynamics mechanism of action enzyme actions receptors recent drugs asthma hesperetin lead reactive oxygen species paw rat anti-inflammatory edema carageenan simvastatin statins hypolipidaemia prednisolone vaso-occlusive crisis thallasemia sickle cell anaemia pharmacology addiction health medicine antithyroid drus basic hypothyroid hyperthyroid short thyroid endocrinology