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Sickle cell anaemia 2

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Sufia Irshad
Sufia Irshad

Sickle-cell anaemia is a genetic blood disorder caused by a mutation in the haemoglobin gene. It causes red blood cells to become misshapen and block small blood vessels, leading to pain and anaemia. If both parents are carriers of the sickle-cell allele, there is a 25% chance their child will have sickle-cell anaemia, as shown through a Punnett square. Treatments aim to prevent pain crises and complications but do not cure the condition, though bone marrow transplants potentially offer a cure.

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Sickle-Cell Anaemia By Sufia Irshad and Unaisa Khan
What is It? A genetic disorder which causes some red blood cells to go out of shape. It is caused by a faulty recessive allele which codes for haemoglobin (protein that carries o2 found in blood).
How is it Passed on? QUESTION If both the mother and father is a carrier of sickle-cell allele, what is the likelihood that their child would get sickle-cell anaemia? Fill in the punnet square to show all options.
AA Aa Aa aa
Symptoms? Severe Pain sickle cells block tiny vessels Anaemia damaged cells cant be replaced fast enough by the spleen Tiredness because of shortage of oxygen
Advantages A carrier of sickle-cell anaemia is less likely to catch malaria. A carriers condition is known as sickle-cell trait. The frequency of the sickle-cell allele is higher in places with a high count of malaria. This process is called natural selection. People who have one or two sickle-cell alleles have a much higher resistance against malaria then those who have two normal haemoglobin alleles.
Treatments? Most treatments avoid crisis and pain, but do not cure sickle-cell anaemia. Usually, doctors prescribe Antibiotics-to avoid infection Pain relieving medications There is a possible cure- bone marrow transplant, however there is a risk of death in this procedure.
Test Your Knowledge Now complete the questions on the sheet
Video Rosalind's Story http://www.nhs.uk/Conditions/Sickle- cell-anaemia/Pages/Diagnosis.aspx

More Related Content

Sickle cell anaemia 2

  • 1. Sickle-Cell Anaemia By Sufia Irshad and Unaisa Khan
  • 2. What is It? A genetic disorder which causes some red blood cells to go out of shape. It is caused by a faulty recessive allele which codes for haemoglobin (protein that carries o2 found in blood).
  • 3. How is it Passed on? QUESTION If both the mother and father is a carrier of sickle-cell allele, what is the likelihood that their child would get sickle-cell anaemia? Fill in the punnet square to show all options.
  • 4. AA Aa Aa aa
  • 5. Symptoms? Severe Pain sickle cells block tiny vessels Anaemia damaged cells cant be replaced fast enough by the spleen Tiredness because of shortage of oxygen
  • 6. Advantages A carrier of sickle-cell anaemia is less likely to catch malaria. A carriers condition is known as sickle-cell trait. The frequency of the sickle-cell allele is higher in places with a high count of malaria. This process is called natural selection. People who have one or two sickle-cell alleles have a much higher resistance against malaria then those who have two normal haemoglobin alleles.
  • 7. Treatments? Most treatments avoid crisis and pain, but do not cure sickle-cell anaemia. Usually, doctors prescribe Antibiotics-to avoid infection Pain relieving medications There is a possible cure- bone marrow transplant, however there is a risk of death in this procedure.
  • 8. Test Your Knowledge Now complete the questions on the sheet
  • 9. Video Rosalind's Story http://www.nhs.uk/Conditions/Sickle- cell-anaemia/Pages/Diagnosis.aspx

Editor's Notes

  1. Give everyone a worksheet with a punnet square design for them to draw the options. Get them to draw answer on board.
  2. Before showing the reasons for the symptoms, ask the students for their answers. 3 symptoms=3 answers