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thyroid malignancy thyroid carcinoma copd emphysema chronic bronchitis anemia nephrocalcinosis diarrhea wilson's disease hepatitis c diabetes mellitus type ii dm ii subarachnoid hemorrhage sah pseudogout crystal arthritis gout malara malarial drugs goitre shock antipsychotics psychiatry clozapine schizophrenia vasculitis internal medicine medicine small vessel goitre symptoms goitre signs thyroid treatment goitre management goitre investigations