狠狠撸

animal handling acute oral toxicity oral drug administration handling of mice and rats gavage needle rat and mice glp acute dermal corrosion acute dermal irritation oecd 404 life sciences rabbit study eye corrosion oecd 405 oecd acute eye irritation toxicology biotechnology pharmaceutical oecd 402 dermal toxicity acute pre-clinical drug administration clinical observations topical application freund's complete adjuvant intradermal injection buehler test guinea pig maximisation test handling of guinea pig skin sensitisation oecd 406 oecd 425 up-and-down procedure udp acute class method oecd 423 eschar edema erythema handling of rabbit grading of skin rodents and non rodents