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dentistry nickel titanium properties niti endodontics niti instruments root canal ecosystem operative instruments handpiece dental burs instruments in conservative dentistry quorum sensing primary intraradicular infection microbial identification community lifestyle biofilm community-based microbial pathogenesis bacterial intercommunication bacterial interactions k3 files mtwo protaper next flexmaster wave one files endo express revo-s sequence dental operating microscope loupes magnification endodontics ergonomics in endodontics medicine health healthcare treatment cosmetic dentistry courses the principle cells of the pulp components of dental pulp apical foramen functions of pulpal extracellular matrix the pathways of collagen synthesis organization of cells in the pulp disorders of the dental pulp accessory canal advances in pulp vitality testing. functions of dental pulp coronal and radicular pulp matrix and ground substances vasculature and lymphatic supply innervation of dentin- pulp complex virulence factors mechanisms of microbial pathogenicity treatment failure. secondary/persistent infections microbial ecology spatial distribution of the microbiota diversity of the endodontic microbiota stem cells