This article discusses the roles that gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) play in the pathogenesis of type 2 diabetes. GIP and GLP-1 are incretin hormones that are released from the small intestine in response to food intake and stimulate insulin secretion. The article reviews studies showing that GIP may lose its ability to stimulate insulin secretion in patients with type 2 diabetes, while GLP-1 remains effective.
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1. Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesi...
Michael A Nauck; Birgit Baller; Juris J Meier
Diabetes; Dec 2004; 53, ProQuest Medical Library
pg. S190
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