The study on gene regulatory networks is an emerging field in the bioscience. In our lab, we use the systematic analysis to examine how the endoderm forms using zebrafish as a model organism. To decipher the underlying mechanism of embryo specification and differentiation, we first survey the literature to reconstruct gene regulatory networks (GRNs) underlying development from literature and built a website for our result. The development of early embryo is control by a cascade of transcription factors and signal transduction machinery. We further analysis the subcircuits for sox32 and sox17, the evolutionary conserved Kernel of gata5, gata6 and otx, and the transcription regulation of si...
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