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cognition bioinformatics machine learning cognitive computing neuroinformatics whole brain emulation cognitive systems semiotic triad cognitive compuring semantics symbol psychology high performance computing brainstorming large scale brain computational intelligence modelling three-dimensional structure mean-field theory of meta-learning inhibitors cheminformatics clustering post-translational modifications ligands proteins chemoinformatics meta-learning landau theory high-throughput screening virtual screening phosphorylation denis noble information flow systems biology living systems