The document discusses Expanded Dengue Syndrome (EDS), which was defined by the WHO in 2011 as unusual manifestations of dengue infection involving severe dysfunction of single or multiple organs like the liver, kidneys, brain or heart. EDS was not defined in 2009. The document notes that EDS involves conditions beyond dengue fever or hemorrhagic fever, and can be associated with underlying host conditions, co-infections, or profound shock. EDS includes dengue liver failure, acute respiratory distress syndrome, multiple organ dysfunction syndrome, hemophagocytic lymphohistiocytosis, encephalitis, and acute kidney injury. Treatment for EDS is organ-specific supportive care.
11. EDS Definition : WHO
Unusual manifestations of patients with severe organ (single / multiple organ) involvement
such as liver, kidneys, brain or heart associated with dengue infection(WHO 2011), which are
not usually explained by dengue fever or dengue hemorrhagic fever.
They could be associated with underlying host conditions (Infants, DM etc) or co-infections
(Malaria, typhoid etc) or as a complication of profound shock.
Kadam DB, Salvi S, Chandanwale A. Expanded Dengue. J Assoc Physicians India. 2016 Jul;64(7):59-63.
Umakanth M, Suganthan N. Unusual manifestations of dengue fever: a review on expanded dengue
syndrome. Cureus 2020;12:e10678
15. Expanded Dengue Syndrome is not about fluids
But about severe organ dysfunction
Including
Dengue Liver Failure
Dengue ARDS
Dengue MODS
Including
Dengue HLH
Dengue Encephalitis
Dengue AKI
17. Name Dr Maninder Singh Dhaliwal
Qualification MD Paeds, DAA,
Fellowship Ped Critical Care 2010
Designation Senior Consultant
PICU & Ped Pulmonology
Institution Amrita Hospital, Faridabad
Thank You
Lets Win Against Dengue
Editor's Notes
the classifi cation into levels of severity has a high potential for being of practical use in
the clinicians decision as to where and how intensively the patient should be observed
and treated (i.e. triage, which is particularly useful in outbreaks), in more consistent
reporting in the national and international surveillance system, and as an end-point
measure in dengue vaccine and drug trials.
the classifi cation into levels of severity has a high potential for being of practical use in
the clinicians decision as to where and how intensively the patient should be observed
and treated (i.e. triage, which is particularly useful in outbreaks), in more consistent
reporting in the national and international surveillance system, and as an end-point
measure in dengue vaccine and drug trials.