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teratogenicity teratogens pregnancy drugs icsr psur safety evaluation clinical trials new drugs in malaria recent treatment of malaria malaria vaccine malaria pharmacotherapy of cardiac arrhythmias lidocaine amiodarone digoxin ventricular flutter ventricular fibrillation psvt atrial flutter atrial fibrillation cardiac arrhythmias pharmacotherapy who net carat criteria antimicrobial stewardship antibiotic policy rational use of antibiotics