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copd osa asthma lung pneumonia sleep sleep disorder cardiology respiratory pulmonary smoking systolic murmur antibiotic medical students doctors vaping ecigarettes evali pleural effusion coronavirus respiratory system ncov2019 pregnancy ards n acetylcystein journal inhaler therapy dpi mdi china virus diffuse parenchymal lung disease interstitial lung disease dpld bronchitis chronic obstructive pulmonary disease emphysema consolidation community acquired pneumonia obesity sleep apnoea metabolic syndrome napcon ild abstract bronchiectasis presentation polysomnography diastolic murmurs cardiovascular disease cardiovascular disorders