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pharma migraine rheumatoid arthritis gout iopamide iohexol ionic contrast media iodinated compounds radiopaques double contrast radionuclides radio contrast media diagnostic agents sympathetic nervous system adrenergic cholinergic parasympathetic nervous system autonomic nervous system alcoholism intoxication methanol disulfiram ethanol alcohol ergotamine anakinra etanercept infliximab azathioprine febuxostat triptans sumatriptan biologicals probenecid allopurinol colchicine