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single-use downstream processing technologies machine level technologies global health recombinant vector technologies influenza pandemic preparedness biologics production technology transfer just-in-time production models egg-based manufacturing investment molecular level technologies manufacturing enterprise production facilities poultry spf eggs pharmaceuticals just-in-time low-cost gmp manufacturing embryonated hen eggs agriculture health economics hiv/aids afrivax secondlife optaids afriheart liberia midwifery clinical ebola malaria sierra leone traditional medicine healthcare user interaction design product design user interface uid uix