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diabetes mellitus type 2 graves disease hypothyroidism short stature myasthenia gravis pcos diabetes mellitus heart failure copd gliclazide virilizing tumor virilization congenital adrenla hyperplasia obesity gdm pregnancy rickets osteomalacia kyphoscoliosis partial ptosis metabolic syndorme neck swelling graves' disease genetics gestational diabetes irregular menstruation weight gain hirsutism sweating acromegaly headache pituitary tumor hypopituitarism empty sella cushing's acth ketoconazole cortisol incretin vildavliptin polisosis hashimoto growth hormone hyponatremia adrenal insufficiency weakness vomiting hypogonadism vitiligo update insulin modern breathlessness weight loss pigmentation