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This document outlines guidelines for investigating thrombophilia. Patients who should be investigated include those with recurrent venous thrombosis, a first venous thrombosis under age 40, an unusual venous thrombosis, unexplained neonatal thrombosis, or recurrent miscarriages. General investigations include D-dimer and full blood count levels. Specific investigations identify deficiencies in naturally occurring anticoagulants like antithrombin, protein C, and protein S, as well as screening for coagulation factor inhibitors and antibodies. Genetic testing can identify mutations like Factor V Leiden that increase thrombosis risk. The results determine if further investigation or treatment is needed.Read less