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trials management target contouring guidelines surgery preoperative radiotherapy evidence parotid cancers radiotherapy trastuzumab herceptin breast cancer treatment low grade glioma disscussion parsport trial details tumor lysis syndrome hypercalcemia of malignancy telomere senescence cancer biology titan trial immunotherapy chemotherapy dose escalation evidence based management pathology types high grade glioma evidences qol long course short course rectal cancers interval rectal cancer anatomy parotid gland carcinoama classification staging tumor suppressors