This document presents a case study of a patient with non-celiac gluten sensitivity (NCGS). The patient had recurring allergic rhinitis and blood tests ruled out celiac disease. Though the patient received allergy vaccination, symptoms like nasal stuffiness, GI issues, and fatigue persisted. An elimination diet removing gluten and milk for 3 months provided relief from these symptoms. This suggests the patient has NCGS since symptoms improved without gluten. NCGS involves sensitivity to gluten without the antibodies or intestinal damage of celiac disease.
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Kerly Maire Servilieri Poster GF 2015
1. NONNON--COELIAC GLUTENCOELIAC GLUTEN SENSITIVITYSENSITIVITY
A Patient's Case
Kerly Maire Servilieri1, Anne Buus2
1 Community Pharmacy, Aarhus Vejlby Apotek, Denmark
2 Allergy and Lung Clinic Aarhus, Denmark
A recurring patient with
severe allergic rhinitis
(hay fever) was by a
pharmacy referred to a
physician, who referred
her to an allergy
specialist.
Blood tests
showed a high
Timothy-grass
antibody.
New blood tests
was negative
for
transglutaminas
e antibodies and
DQ2/DQ8, and
therefore it
almost certainly
wasnt coeliac
The patient had a
deviation from the
normal range with
respect to
cholesterol, LDL,
But...
The patient subsequently
received three years of allergy
vaccination but some symptoms
still persisted (stuffy nose, GI
symptoms and fatigue),
indicating that this patient could
have non-coeliac gluten
sensitivity (NCGS).
Pathogenesis
Not autoimmune
Not allergic
(Innate immunity?)
Gluten
sensitivity
Allergic
Wheat allergy
Food Allergy WDEIA Contact Respiratory
Autoimmune
Coeliac
DiseaseGluten Ataxia Dermatitis
herpetiformis
Gluten Related
Disorders
Gluten
sensitivity
NCGS - Non-coeliac gluten sensitivity - has been coined to
describe those individuals who cannot tolerate gluten and
experience symptoms similar to those with coeliac disease
but yet who lack the same antibodies and intestinal damage
as seen in coeliac disease. (celiaccentral.org)
..
The pictures below and to the right show
the patient and the allergist interviewed
by Jack Fridthjof -TV Aarhus.
disease. cholesterol, LDL,
iron, D-vitamine,
bone-marrov
function and
average blood
sugar, which is
common for most
gluten sensitive
patients.
Since diagnosis of NCGS is based on
exclusion criteria, i.e. a period without
gluten, the allergist ordered an
abstinence of gluten and milk (milk
protein cross react with gliadin) for 3
months to observe the symptoms.
After two
weeks
The patient
experienced a relieve
of stuffy nose,
abdominal pain,
indigestion, bloating,
constipation and
nausea.
After two
months
Food Allergy WDEIA Contact
Urticaria
Respiratory
Allergy Symptomatic Silent Potential
Sapone et al. BMC Medicine 2012
Further symptoms
were relieved,
which included;
weakness,
exhaustion, muscle
pain, memory
problems and mild
depression.