Sunlight and Skin Cancer
- 1. Karen Zapata Montenegro Dermatology and Dermatology surgery CSS
- 3. Introduction UV Radiation Concept UV radiation damage Photoprotection
- 10. Concept
- 11. Isaac Newton. Colors phenomenon1666 William Herschel. Infrared radiation 1800 Johann Ritter. Ultraviolet radiation1801 Diffey B. Methods. 2002; 28: 4-13
- 12. Ultraviolet light or ultraviolet radiation? beyond violet Exposure to UV and its several sequellae 1932 Copenhaguen UVC Maverakis E, et al. Journal of Autoimmunity. 2010; 34: 47-57
- 14. Less than 9% UV
- 15. Elliptical orbit 3.4 % perihelion (January 3) Aphelion (July 5) 7% UVR variation UV radiation
- 17. UVB 5% UVA 95% UVB causes 80% skin damage Clouds decrease UV radiation Chlorofluorocarbon decreases ozone layer Maverakis E, et al. Journal of Autoimmunity. 2010; 34: 47-57
- 18. Measure of the amount UVR at the surface, during maximum radiation Scale 0-11 1 unit = 25 miliWatt/m2 UV-B index
- 19. Snow Desert area 90% 5% 15-30%
- 22. Elevates mood and improves energy
- 23. 5 to 20 minutes of daily exposure Vitamin D production
- 24. Skin cancer
- 29. An estimaded 3.5 millions of new cases each year in USA. 1/5 during lifetime. The most common skin cancer. Outdoor activities UV artificial sources Ozone layer Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13
- 30. Most common cancer in humans 3-8% of annual increase since 1960 Firm association with UV exposure 40 -50% recurrent CBC 80% older than 60 year Madan V, Lear J, Szeimies R. Lancet. 2010; 375:373-85
- 31. Intermittent exposure Childhood exposureCBC Chronic exposure CEC
- 32. 3-7% increase since 1970 Annual incidence 7.89 to 22.52 for each 100000 More related with mortality Kanavy H, Gerstenblith M. Seminars in cutaneous Medicine and surgery. 2011; 222-8
- 34. Melanoma geographical distribution is bigger next to this area. 1% decrease in ozone layer increase melanoma mortality 1-2%. Kanavy H, Gerstenblith M. Seminars in cutaneous Medicine and surgery. 2011; 222-8
- 35. Chronic and intermittent Indoor tanning Skin cancer risk factor since 2009
- 36. High-altitude regions tend to have a higher melanoma rate that may be related to the higher UV fluences (J/cm2) noted at these sites
- 37. Other diseases
- 38. Key points
- 39. Gilaberte Y, Gonz叩lez S. Actas Dermo-Sifiliogr叩ficas. 2010; 101: 659-72
- 40. Gilaberte Y, Gonz叩lez S. Actas Dermo-Sifiliogr叩ficas. 2010; 101: 659-72
- 41. Sunscreens are photochemical systems that absorb or reflect UV radiation. Frequently use of sunscreens is the best photoprotection strategy. The first sunscreen was marketed in 1930 Actually there are 28 chemical filters in Australia, 26 in Europe and 14 in USA. Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
- 42. Absorption Dispersion UVR Chemical or physical filters Reflection
- 43. La capacidad de eritema depende Longitud de onda de radiaci坦n Fotosensibilidad del individuo DEM uso estudios observacionales SPF = ---------------- MED protected MED unprotected Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
- 44. La capacidad de eritema depende Longitud de onda de radiaci坦n Fotosensibilidad del individuo DEM uso estudios observacionales UVA FP = ---------------- MPD protected MPD unprotected DPM: dosis de pigmento m鱈nima Kockler J, Oelgemoller M, Robertson S, Glass B. Journal of Photochemistry and Photobiology. 2012; 1-17
- 45. FILTERS ACTION SPECTRUM INORGNICOS- FSICOS Di坦xido de titanio al 25% 350 UVA, UVB xido de cinc al 25% 350 UVA, UVB ORGNICOS - QUMICOS Filtros para UVA Benzofenonas Oxibenzonas al 6% 288-325 UVB, UVA II Sulisobenzonas al 10% 366 UVA Dioxibenzona al 3% 352 UVA Dibenzolimetanos Avobenzona 3% 360 UVA1 Antralatos Medalimato al 3% 340 UVAII Ecamsul (mexorilo SX) 345 UVB, UVA cido terephtalilideno diaalcanforsulf鱈nico al 10%
- 46. FILTERS ACTION SPECTRUM Filtros para UVB Aminobenzoatos (derivados del PABA) PABA al 1 5% 283 UVB Padimato O (octil dimetil PABA) al 8% 311 UVB Cinamatos Cinoxato al 3% 289 UVB Octinoxate (octil metoxicinamato) al 7.5% 311 UVB Salicilatos Octilsalate (octil salicilato) al 5% 307 UVB Homosalat (homentil salicilato) al 15% 306 UVB Trolamina salicilato al 12% 306 UVB Otros Octocrileno al 10% 303 UVB, UVAII Ensulizolo al 4% 310 Metileno-bis-benzotriazolila Tetrametilbutifenol (Tinosorb M) al 10% 305- 360 UVB, UVA Filtro inorg叩nico y org叩nico Bis-etilhexiloxifenol metoxifenil triazina (Tinosorb S) al 10% 310- 340 Moreno M, Moreno L. Rev Asoc Colomb Dermatol. 2009; 10: 1-9
- 47. 20 min before and 2 - 3 hours SPF 30 (97.5 UVB) 370nm High UVA protection SPF 30 UVA high protection
- 48. 50- 80% solar damage is before 18 Correct solar protection Walker D. Journal of Pediatric nursing. 2011 Article in press
- 49. UPF higher than 40 Dark colors, nylon and polyester
- 50. DFMO: difluorometilornitina Camp et al. Semin Cutan Med Surg. 2011; 30: 6-13