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mehis pold clinical genetics genomics eomix breast cancer oncogene cholesterol biosynthesis cholesterol cancer cancer risk human disease triple negative breast cancer poor prognosis breast cancer ivd 510k pre-market submission pre-market notification er estrogen positive standard endocrine therapy targeted therapy for breast cancer tamoxifen hormone treatment refractory statins breast cancer stratification poor prognosis treatment response ttyh1 tweety homolog 1 endocrine therapy estrogen positive breast cancer tamoxifen response chromosomal locus 11q13 tamoxifen resistance myc choromosomal locus 8q24 cyclin d1 stratification of breast cancer art3 adp-ribosyl transferase 3 novel marker for breast cancer esr-negative gain-of-function mutation meta-analysis of gene-expression esr esr-positive isocitrate dehydrogenase idh1 estrogen receptor idh2 uqcrh the mitochondrial hinge protein kaplan-meier survival probability proton pump meta-analysis complex iii ubiquinol-cytochrome c reductase cytochrome c cytochrome c1 art in vitro diagnostic device meta-analysis of breast cancer gene expression non-small cell lung cancer alk-fusion diagnostic test tropomyosin genome annotation genome annotation pipeline garage genomics sensitivity and specificity accuracy of genomics start codon start-lost annotation start-lost null-variant comparative genomics disease genomics genomics software disease diagnostis clinical genomics genome annotation pipelins werner syndrome kidney failure heart failure citrullinemia mlh1 wrn slc25a13 gstm1 exome exome sequencing conversion of 7-dehyrocholesterol to cholesterol er breast cancer endocrine therapy response synchronicity between oncogenes and cholesterol bi dhcr7 ccnd1 dyregulation of proto-oncogenes squalene epoxidase dna repair mutation splice site acceptor site tumor suppressor genes dna silent mutations exon-intron boundaries brca1 brca2 interpretation of genetic finding interpretation of human disease predictive genomics automated interpretation of ngs results ngs cosmic alk lung cancer eml4 eml1 somatic variations