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systems biology systems medicine metabolic syndrome metabolism parameter estimation uncertainty analysis eindhoven diabetes m-health data integration identifiability metabolic network modelling computational modeling estimating models of dynamic systems hdl hepatic steatosis adapt verification validation uncertainty quantification regularization genome-scale metabolic models quantitative systems pharmacology lipoprotein distribution profiling biomedical engineering education systems physiology games for health lipoprotein metabolism glucose diabetes self-management education (dsme) human glucoregulatory system physiology-based model mouse models metabolic network aging lxr metabolomics human metabolism differential equation models lipid metabolism fluxomics