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radiation oncology radiotherapy cancer medicine radiophysics carcinoma health healthcare brain tumors high grade glioma radiation linear accelerator education medical treatment research premanagement tumor carcinoma rectum modern radiotherapy trial cyberknife endometrial carcinoma endometrium lymphatic system prostate carcinoma prostate external beam radiation machine learning biotechnology technology radiosurgery stereotatic radiosurgery necrosis radiation necrosis bevacizumab jounral club chemotherapy stupp trial temozolamide long course radiotherapy short course radiotherapy breast cancer