Cyclo oxygenase pathway
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This document discusses the biochemical process that occurs after tissue injury, where phospholipase A2 acts on membrane phospholipids to release arachidonic acid, which is then converted by cyclooxygenase enzymes into prostaglandins like prostacyclin, PGE2, PGF2, and thromboxanes like TXA2. These prostaglandins and thromboxanes have various effects on the endothelium, smooth muscles, and platelets.
Cyclo oxygenase pathway
- 2. Trauma Membrane Phospholipids Tissue Injury Phospholipase A2 Arachidonic Acid Prostaglandins Cyclooxygenase (COX1 / COX2)NSAID Prostacyclin PGI2 Prostaglandins PGE2 PGF2 Thromboxanes TXA2 Endothelium Smooth Muscles Platelets