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pain anesthesia chronic pain painless labor radiofrequency low back pain lumbar discectomy endoscopic discectomy disk herniation regional anesthesia djd discopathy general anesthesia osteoarthritis intubation local anesthesia pain control peld spinal acute pain emergency department painless delivery patient safety analgesia epidural stem cell therapy regenerative medicine exosome patient_safety bupivacaine ropivacaine mechanical ventilation oxygenation ventilator nurse icu anesthesiology resident crf anesthesia ihd anesthesia copd anesthesia pcea delivery labore entonox nvd childbirth pca breast feeding airway airway devices lma ventilation laryngoscopy pain management cancer pain esp block erector spinae plane block pain killers discogenic pain degenerative disc disease tissue engineering iasp local anesthetic infancy pediatric geriatric elderly diabetic obese local anaesthesia regional anaesthesia glottis endoscopic surgery endoscopy lbp rfid headache neck pain cervical pain cervicogenic headache ldh kambin's triangle vaginal delivery knee oa knee rf degenerative joint disease surgery postoperative pain