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insulin pcsk9 diabetic dyslipidaemia wegener"s granulomatosis anca vasculitis giant cell arteritis sle viral arthritis osteoarthritis rheumatoid arthritis pmr gout hepatitis herpes virus haart transudative effusion empyema pleurodesis parapneumonic effusion thoracentesis light's criteria sunshine vitamin glyburide breastfeeding metabolic syndrome gdm constipation microscopic colitis coeliac disesae red flags rome iv criteria iglarlixi slt2 inhibitors dpp4 inhibitors metformin t2diabetes obstructive lung disease spirometry pulmonary edema congestive cardiac failure copd wheezing shortness of breath