際際滷shows by User: DevonFagel / http://www.slideshare.net/images/logo.gif 際際滷shows by User: DevonFagel / Tue, 22 Jul 2014 13:49:57 GMT 際際滷Share feed for 際際滷shows by User: DevonFagel The Role of Fibroblast Growth Factors in Cortical Regeneration After Perinatal Hypoxia: A Model For Neurological Recovery In Premature Children /slideshow/fagel-thesis-2013/37250643 fagelthesis2013-140722134957-phpapp01
Chronic perinatal hypoxia causes a significant loss of total brain volume, brain weight and cortical neuron number. These measures are completely reversed following recovery in normoxic conditions. Yet, the cellular and molecular mechanisms underlying this plasticity are not well understood. Here, we show that hypoxia from postnatal days 3 (P3) to 10-11 causes a 30% decrease in cortical neurons and a 24% decrease in cortical volume. Excitatory neuron numbers were completely recovered one month after the insult, but the mice showed a residual deficit in GABAergic interneurons. In contrast, hypoxic mice carrying a disrupted fibroblast growth factor receptor-1 (Fgfr1) gene in GFAP+ cells [Fgfr1 conditional knock-out (cKO)], showed a persistent loss of excitatory cortical neurons and an increased interneuron defect. Labeling proliferating progenitors at P17-18 revealed increased generation of cortical NeuN+ and Tbr1+ neurons in wild-type mice subjected to hypoxic insult, whereas Fgfr1 cKO failed to mount a cortical neurogenetic response. Hypoxic wild-type mice also demonstrated a twofold increase in cell proliferation in the subventricular zone (SVZ) at P17-18 and a threefold increase in neurogenesis in the olfactory bulb (OB) at P48-49, compared with normoxic mice. In contrast, Fgfr1 cKO mice had decreased SVZ cell proliferation and curtailed reactive neurogenesis in the OB. Thus, the activation of Fgfr1 in GFAP+ cells is required for neuronal recovery after perinatal hypoxic injury. In contrast, there is incomplete recovery of inhibitory neurons following injury, which may account for persistent behavioral deficits in adult mice following early perinatal injury.]]>
Chronic perinatal hypoxia causes a significant loss of total brain volume, brain weight and cortical neuron number. These measures are completely reversed following recovery in normoxic conditions. Yet, the cellular and molecular mechanisms underlying this plasticity are not well understood. Here, we show that hypoxia from postnatal days 3 (P3) to 10-11 causes a 30% decrease in cortical neurons and a 24% decrease in cortical volume. Excitatory neuron numbers were completely recovered one month after the insult, but the mice showed a residual deficit in GABAergic interneurons. In contrast, hypoxic mice carrying a disrupted fibroblast growth factor receptor-1 (Fgfr1) gene in GFAP+ cells [Fgfr1 conditional knock-out (cKO)], showed a persistent loss of excitatory cortical neurons and an increased interneuron defect. Labeling proliferating progenitors at P17-18 revealed increased generation of cortical NeuN+ and Tbr1+ neurons in wild-type mice subjected to hypoxic insult, whereas Fgfr1 cKO failed to mount a cortical neurogenetic response. Hypoxic wild-type mice also demonstrated a twofold increase in cell proliferation in the subventricular zone (SVZ) at P17-18 and a threefold increase in neurogenesis in the olfactory bulb (OB) at P48-49, compared with normoxic mice. In contrast, Fgfr1 cKO mice had decreased SVZ cell proliferation and curtailed reactive neurogenesis in the OB. Thus, the activation of Fgfr1 in GFAP+ cells is required for neuronal recovery after perinatal hypoxic injury. In contrast, there is incomplete recovery of inhibitory neurons following injury, which may account for persistent behavioral deficits in adult mice following early perinatal injury.]]> Tue, 22 Jul 2014 13:49:57 GMT /slideshow/fagel-thesis-2013/37250643 DevonFagel@slideshare.net(DevonFagel) The Role of Fibroblast Growth Factors in Cortical Regeneration After Perinatal Hypoxia: A Model For Neurological Recovery In Premature Children DevonFagel Chronic perinatal hypoxia causes a significant loss of total brain volume, brain weight and cortical neuron number. These measures are completely reversed following recovery in normoxic conditions. Yet, the cellular and molecular mechanisms underlying this plasticity are not well understood. Here, we show that hypoxia from postnatal days 3 (P3) to 10-11 causes a 30% decrease in cortical neurons and a 24% decrease in cortical volume. Excitatory neuron numbers were completely recovered one month after the insult, but the mice showed a residual deficit in GABAergic interneurons. In contrast, hypoxic mice carrying a disrupted fibroblast growth factor receptor-1 (Fgfr1) gene in GFAP+ cells [Fgfr1 conditional knock-out (cKO)], showed a persistent loss of excitatory cortical neurons and an increased interneuron defect. Labeling proliferating progenitors at P17-18 revealed increased generation of cortical NeuN+ and Tbr1+ neurons in wild-type mice subjected to hypoxic insult, whereas Fgfr1 cKO failed to mount a cortical neurogenetic response. Hypoxic wild-type mice also demonstrated a twofold increase in cell proliferation in the subventricular zone (SVZ) at P17-18 and a threefold increase in neurogenesis in the olfactory bulb (OB) at P48-49, compared with normoxic mice. In contrast, Fgfr1 cKO mice had decreased SVZ cell proliferation and curtailed reactive neurogenesis in the OB. Thus, the activation of Fgfr1 in GFAP+ cells is required for neuronal recovery after perinatal hypoxic injury. In contrast, there is incomplete recovery of inhibitory neurons following injury, which may account for persistent behavioral deficits in adult mice following early perinatal injury. <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/fagelthesis2013-140722134957-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Chronic perinatal hypoxia causes a significant loss of total brain volume, brain weight and cortical neuron number. These measures are completely reversed following recovery in normoxic conditions. Yet, the cellular and molecular mechanisms underlying this plasticity are not well understood. Here, we show that hypoxia from postnatal days 3 (P3) to 10-11 causes a 30% decrease in cortical neurons and a 24% decrease in cortical volume. Excitatory neuron numbers were completely recovered one month after the insult, but the mice showed a residual deficit in GABAergic interneurons. In contrast, hypoxic mice carrying a disrupted fibroblast growth factor receptor-1 (Fgfr1) gene in GFAP+ cells [Fgfr1 conditional knock-out (cKO)], showed a persistent loss of excitatory cortical neurons and an increased interneuron defect. Labeling proliferating progenitors at P17-18 revealed increased generation of cortical NeuN+ and Tbr1+ neurons in wild-type mice subjected to hypoxic insult, whereas Fgfr1 cKO failed to mount a cortical neurogenetic response. Hypoxic wild-type mice also demonstrated a twofold increase in cell proliferation in the subventricular zone (SVZ) at P17-18 and a threefold increase in neurogenesis in the olfactory bulb (OB) at P48-49, compared with normoxic mice. In contrast, Fgfr1 cKO mice had decreased SVZ cell proliferation and curtailed reactive neurogenesis in the OB. Thus, the activation of Fgfr1 in GFAP+ cells is required for neuronal recovery after perinatal hypoxic injury. In contrast, there is incomplete recovery of inhibitory neurons following injury, which may account for persistent behavioral deficits in adult mice following early perinatal injury.
The Role of Fibroblast Growth Factors in Cortical Regeneration After Perinatal Hypoxia: A Model For Neurological Recovery In Premature Children from Devon Fagel, MD, JD
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Ancient Remedy for Modern Medicine]]>
Ancient Remedy for Modern Medicine]]> Tue, 22 Jul 2014 13:20:48 GMT /slideshow/maggot-therapy/37249583 DevonFagel@slideshare.net(DevonFagel) Maggot Therapy DevonFagel Ancient Remedy for Modern Medicine <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/maggottherapy-140722132048-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Ancient Remedy for Modern Medicine
Maggot Therapy from Devon Fagel, MD, JD
]]> 7225 9 https://cdn.slidesharecdn.com/ss_thumbnails/maggottherapy-140722132048-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Vaginal Birth After Cesarean /slideshow/vaginal-birth-after-cesarean/37249510 vaginalbirthaftercesarean-140722131837-phpapp02
Risk to Patient, Provider and Public]]>
Risk to Patient, Provider and Public]]> Tue, 22 Jul 2014 13:18:37 GMT /slideshow/vaginal-birth-after-cesarean/37249510 DevonFagel@slideshare.net(DevonFagel) Vaginal Birth After Cesarean DevonFagel Risk to Patient, Provider and Public <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/vaginalbirthaftercesarean-140722131837-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Risk to Patient, Provider and Public
Vaginal Birth After Cesarean from Devon Fagel, MD, JD
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Evaluation and Treatment]]>
Evaluation and Treatment]]> Fri, 18 Jul 2014 18:15:58 GMT /slideshow/hearing-loss-37141176/37141176 DevonFagel@slideshare.net(DevonFagel) Hearing Loss DevonFagel Evaluation and Treatment <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/hearingloss-140718181558-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Evaluation and Treatment
Hearing Loss from Devon Fagel, MD, JD
]]> 475 5 https://cdn.slidesharecdn.com/ss_thumbnails/hearingloss-140718181558-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Craniosynostosis /slideshow/craniosynostosis-37141125/37141125 craniosynostosis-140718181247-phpapp01
Surgical Treatment and Neurodevelopmental Outcome]]>
Surgical Treatment and Neurodevelopmental Outcome]]> Fri, 18 Jul 2014 18:12:47 GMT /slideshow/craniosynostosis-37141125/37141125 DevonFagel@slideshare.net(DevonFagel) Craniosynostosis DevonFagel Surgical Treatment and Neurodevelopmental Outcome <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/craniosynostosis-140718181247-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Surgical Treatment and Neurodevelopmental Outcome
Craniosynostosis from Devon Fagel, MD, JD
]]> 13850 7 https://cdn.slidesharecdn.com/ss_thumbnails/craniosynostosis-140718181247-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Bench to Bedside /slideshow/child-abuse-neglect-37140756/37140756 childabuseneglect-140718175016-phpapp01
Neurodevelopmental Effects of Child Abuse & Neglect]]>
Neurodevelopmental Effects of Child Abuse & Neglect]]> Fri, 18 Jul 2014 17:50:16 GMT /slideshow/child-abuse-neglect-37140756/37140756 DevonFagel@slideshare.net(DevonFagel) Bench to Bedside DevonFagel Neurodevelopmental Effects of Child Abuse & Neglect <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/childabuseneglect-140718175016-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Neurodevelopmental Effects of Child Abuse &amp; Neglect
Bench to Bedside from Devon Fagel, MD, JD
]]> 394 3 https://cdn.slidesharecdn.com/ss_thumbnails/childabuseneglect-140718175016-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Peripheral Nerve Sheath Tumors /DevonFagel/peripheral-nerve-sheath-tumors peripheralnervesheathtumors-140718122606-phpapp01
Detection, Prognosis and Treatment of Neurofibromas ]]>
Detection, Prognosis and Treatment of Neurofibromas ]]> Fri, 18 Jul 2014 12:26:06 GMT /DevonFagel/peripheral-nerve-sheath-tumors DevonFagel@slideshare.net(DevonFagel) Peripheral Nerve Sheath Tumors DevonFagel Detection, Prognosis and Treatment of Neurofibromas <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/peripheralnervesheathtumors-140718122606-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Detection, Prognosis and Treatment of Neurofibromas
Peripheral Nerve Sheath Tumors from Devon Fagel, MD, JD
]]> 5975 5 https://cdn.slidesharecdn.com/ss_thumbnails/peripheralnervesheathtumors-140718122606-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Congenital Heart Defects /slideshow/congenital-heart-defects-37132721/37132721 congenitalheartdefects-140718122146-phpapp01
Management of Single Ventricle Physiology]]>
Management of Single Ventricle Physiology]]> Fri, 18 Jul 2014 12:21:46 GMT /slideshow/congenital-heart-defects-37132721/37132721 DevonFagel@slideshare.net(DevonFagel) Congenital Heart Defects DevonFagel Management of Single Ventricle Physiology <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/congenitalheartdefects-140718122146-phpapp01-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> Management of Single Ventricle Physiology
Congenital Heart Defects from Devon Fagel, MD, JD
]]> 4984 7 https://cdn.slidesharecdn.com/ss_thumbnails/congenitalheartdefects-140718122146-phpapp01-thumbnail.jpg?width=120&height=120&fit=bounds presentation Black http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 Medical Malpractice 101 /DevonFagel/medical-malpractice-101 medicalmalpractice101-140618155153-phpapp02
A Surgeon's Guide to Law and Tort Reform]]>
A Surgeon's Guide to Law and Tort Reform]]> Wed, 18 Jun 2014 15:51:53 GMT /DevonFagel/medical-malpractice-101 DevonFagel@slideshare.net(DevonFagel) Medical Malpractice 101 DevonFagel A Surgeon's Guide to Law and Tort Reform <img style="border:1px solid #C3E6D8;float:right;" alt="" src="https://cdn.slidesharecdn.com/ss_thumbnails/medicalmalpractice101-140618155153-phpapp02-thumbnail.jpg?width=120&amp;height=120&amp;fit=bounds" /><br> A Surgeon&#39;s Guide to Law and Tort Reform
Medical Malpractice 101 from Devon Fagel, MD, JD
]]> 2599 9 https://cdn.slidesharecdn.com/ss_thumbnails/medicalmalpractice101-140618155153-phpapp02-thumbnail.jpg?width=120&height=120&fit=bounds presentation White http://activitystrea.ms/schema/1.0/post http://activitystrea.ms/schema/1.0/posted 0 https://cdn.slidesharecdn.com/profile-photo-DevonFagel-48x48.jpg?cb=1728532882 For more than a century, the field of neuroscience fiercely opposed change, insisting the brain to be an immutable organ incapable itself, of change. But thanks to disruptive scientists, we now know that the brain constantly adapts to meet challenges. Likewise, for decades we have been told, healthcare is incapable of reform. Much as the brain responds to adversity, so too, will healthcare. I seek to be a catalyst of this change. I began my legal career fighting to reform orphanages and secure medical services for foster children. Dealt insurmountable odds, I was astounded how they flourished. Yet rather than adopt change, legislators simply closed facilities. This inspired me to alter c... https://www.researchgate.net/profile/Devon_Fagel https://cdn.slidesharecdn.com/ss_thumbnails/fagelthesis2013-140722134957-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/fagel-thesis-2013/37250643 The Role of Fibroblast... https://cdn.slidesharecdn.com/ss_thumbnails/maggottherapy-140722132048-phpapp01-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/maggot-therapy/37249583 Maggot Therapy https://cdn.slidesharecdn.com/ss_thumbnails/vaginalbirthaftercesarean-140722131837-phpapp02-thumbnail.jpg?width=320&height=320&fit=bounds slideshow/vaginal-birth-after-cesarean/37249510 Vaginal Birth After Ce...