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polymerase chain reaction genetic engineering cancer drug discovery biomarkers vector host biotechnology amplication heart biology dna recombinant dna technology genetics biotechnology and pharmaceuticals micro array gel electrophoresis gene therapy cancer virology life cycle virus capsid virion adenovirus nucleic acids nucleotides cell biology genetically modified organism dna profiling dna sequencing metabolomic biomarkers biomarkers prognosis treatment biomarkers epidemiology rna biomarkers proteomic biomarkers dna biomarkers approved biosimilar retacrit biopharmapeutical epoetin alpha epoetin zeta derivative blood innovator's drug biosimilar amgen therapeutics apocynacae cardiac plants medicine drugs natural glycosides herbal dignosis fermentors insulin cholesterol left atrium mycocardial infarction blockage in heart pulse pulmonary vein right atrium right ventricle heart failure 4 chambered aorta left ventricle fda erythropoietin rbc glycosides