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sar classification structure activity relationship mechanism of action moa sulfazecin aztreonam antibacterial resistant to 尾-lactamases medicinal chemistry gram-positive or anaerobic bacteria carbapenems tazobactam combinations of clavulanate potassium clavulanic acid 尾 -lactamases inactivation penicillinase-resistant penicillins instability of 尾-lactams to nucleophiles acylside chain modifications penicillin sar shape of penicillin g cross-linking of the peptidoglycan by transpeptida penicillin general structure 尾-lactamase inhibitors antimicrobial agents structural modifications chemistry of lincosamides clindamycin spectrum gramicidin polymyxin b sulfate bacitracin teicoplanin resistance vancomycin moa vancomycin structure chemistry vancomycin unique characteristics of polypeptides carbapenems structural modifications beta lactamase inhibitors egf-r glr gaba types of receptors docking hansch analysis free wilson analysis qsar pharmacy vinccristine jambul traditional to modern rational drug discovery cadd holistic youth development crises management peace drug discovery drug metabolism penicillin classification penicillin numbering systems penicillin basic ring nomenclature types of lactam penicillin class drugs 尾别迟补-濒补肠迟补尘蝉 selecting a metabolite as a antibiotic history of antibiotics penicillins fries rearrangement williamson synthesis reimer-tiemann reaction kolbe reaction cumene oxidation synthesis & reactions phenols -acidity intracellular receptors gpcr ligand gated ion channels tyrosine kinase satranidazole ornidazole secnidazole tinidazole nitroimidazoles: metronidazole luminal amoebicides cyst form trophozoite form parasitic infections worm infestation thiabendazole tapeworms) roundworm pyrantel praziquantel platyhelminthes (flatworms) piperazine pinworm mebendazole principle of chromatography partition chromatography adsorption chromatography chromatography nitrofurazone nifurtimox metronidazole furazolidone nitrofurantoin nitro-heterocyclic compounds in chemotherapy diiodohydroxyquin (iodoquinol) clioquinol) 8-hydroxyquinolines: quiniodochlor (iodochlorohydr antibiotics: tetracyclines nitazoxanide diloxanide furoate chloroquine dehydroemetine alkaloids: emetine free educational resources free books open educational resources cotrimoxazole prodrugs for sulphonamide reducing toxicity spectrum of action of the sulfonamides mechanisms of action of antibacterials nomenclature of the sulfonamides ionization of sulfonamides sulphonamides norfloxacin sar- substitution variation topoisomerase iv isosteric replacement dissociation dyes types of amines sandmeyer inhibition of tubulin polymerization hookworm helminthiasis flukes or schistosomes flubendazole diethylcarbamazine benzimidazoles and whipworm ancylostomiasis or hookworm infection albendazole drugs acting against leishmaniasis trypanosomicidal drugs triazoles imidazoles allylamines itraconazole ketoconazole mycoses institutional resources hinsberg