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pipeline drugs obesity pharmacotherapy obesity malaria tefenoquine malaria pharmacotherapy amr gram negative bacterial resistance gram negative bacteria therapeutic use exemption sports anabolic steroids nada wada sports drug abuse doping challenges to omics microbiomics metabolomics proteomics transcriptomics epigenomics genomics systems approach precision medicine omics microdosing drug development positron emission tomography pet ayurveda traditional medicine ethnomedicine ethnobotany ethnophamacology mongersen mirikizumab risankizumab apremilast tofacitiib ulcerative colitis crohn's disease inflammatory bowel disease ibd nootropics learning & memory screening transgenic mice anti alzheimer drugs memory learning screening pipeline drugs obesity