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Literature Review
Acknowledgement
Acknowledgment to Assoc. Prof Dr
Sharmini Selvarajah and Ms Chun
Geok Ying for preparation of the
core contents of this presentation.
Literature review
 What it is
 Scientific account of what has
already been published on a specific
topic
 What it is not
 Description or summary of all
published information
Literature reviews must.
1. Be organised around a specific
research question/ topic
2. Synthesize information into a
summary of what is and is not known
3. Identify areas of uncertainty/
controversy
4. Create questions that need further
research
Literature review
 Involves two processes
 1. Searching for information
 2. Critically appraising the literature
Literature Search
using PubMed
Acknowledgement:
Prof. Geert van der Heijden
Contents
 Aim
 Systematic approach to searching
 How to use PubMed
 What not to do
Aim
 Time saving
 Restrict absolute number titles
 Increase number relevant titles
 Reduce Numbers Needed to Read
PubMed: What is it?
 PubMed is a free database accessing
the MEDLINE database of citations,
abstracts and some full text articles on
life sciences and biomedical topics.
 http://www.nlm.nih.gov/services/pubm
ed.html
PubMed: What is in it?
 As of 8 March 2012 ~ over 21 million
citations for biomedical literature
 from MEDLINE, life science journals,
and online books.
 As of November 2011, 5,582 in
Medline
 Different languages []
Systematic
approach
to searching
What to do and what NOT to do
Search strategy in PubMed
 Use knowledge, logic and creativity
 Start with good Research Question
 Population
 Determinant/ Exposure
 Outcome
 Have several terms & synonyms for all
 Be aware: UK / US spelling
Search strategy
 Search #1: Population OR synonyms
 Search #2: Determinant OR synonyms
 Search #3: Outcome OR synonyms
 Search #4: Combine #1, #2 and #3
 Population (#1) AND Determinant (#2)
AND Outcome (#3)
Basic Search Scheme
Population Determinant/
Exposure
Outcome
term term term
Synonym 1 Synonym 1 Synonym 1
Synonym 2 Synonym 2 Synonym 2
Synonym 3 Synonym 3
OR OR OR
AND AND
Boolean operators
 AND
 OR
 NOT
Renal
Renal
Failure
Failure
How to search in PubMed?
 Use Title/ Abstract in search builder,
under Advanced Search tab in
Pubmed
 http://www.ncbi.nlm.nih.gov/pubmed
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
Research Question
 Does renal impairment increase
mortality risk in Type 2 Diabetes
Mellitus?
 Population: Type 2 DM
 Determinant: Renal impairment
 Outcome: Mortality
Example
Population
Type 2 Diabetes
Type 2 diabetics
Non insulin dependent
diabetes
OR
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
Example
Determinant/
Exposure
Renal
Kidney
Albuminuria
Glomerular
OR
OR
OR
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
Example
Outcome
Mortality
Death
OR
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
Example
Population Determinant/
Exposure
Outcome
Type 2 Diabetes Renal Mortality
Type 2 diabetics Kidney Death
Non insulin dependent
diabetes
Albuminuria/
Albumin
Glomerular
AND AND
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
How to MeSH up
your search
What NOT to do
MeSH database
 Medical Subject Headings (MeSH)
 Systematic keyword catalogue
 Related to content
 5 MeSH terms per record
 Based on title and abstract words
 Partially manual process
 Misclassification possible
 MeSH = US spelling
MeSH database
 Author keywords: NOT used
 Only available 3  6 months after
publication
 Adjustment to terms regular
 Eg. 2007
 22 terms removed
 494 terms added
 99 terms replaced
2_1_Pubmed_Search_and_Literature_Review.ppt
What else not to do
 Use sparingly wildcard/ truncation *
Eg. Random*
Look at search details
 Try NOT to use Boolean term NOT
2_1_Pubmed_Search_and_Literature_Review.ppt
Additional tips
 Save search strategy under My NCBI
 Save/ Email collection on articles
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
Nurses and other allied
health researchers
 RQ: What is the level of knowledge and
attitudes of nursing students toward
tuberculosis?
 Reason: To understand and determine
whether there is a need for improvement in
nursing education regarding tuberculosis.
Research Question
 What is the level of knowledge and
attitudes of nursing students toward
tuberculosis?
 Population: Nursing students
 Determinant: Level of knowledge and
attitudes towards TB
 Outcome: None
Example
Population
Nurse ? Nurse
student
nursing
OR
Example
Determinant/
Exposure
attitude
knowledge
behaviour
Behavior
Perception
perceive
OR
OR
OR
OR
OR
Example
Determinant/
Exposure/
(Disease of
interest)
tuberculosis
TB
OR
2_1_Pubmed_Search_and_Literature_Review.ppt
2_1_Pubmed_Search_and_Literature_Review.ppt
Practical session
 Think of a research question and
prepare search terms
 5 minutes
 Go through PubMed search together
Literature search for
Qualitative Studies
 Challenges of search in database:
 Titles are descriptive c.f. RCT which usually has
clear description of population, determinants,
outcome and/or research method
 Eg: Unbearable incidents: Failure to endure the
experience of Illness
 Specific key terms difficult
 Limited standardisation in presentation of abstract
c.f RCT : poor description of study method
 Poor indexing: inconsistent indexing in Pubmed
 Complex and difficult!
Literature search for
Qualitative Studies
 Currently, no establish search strategy for
qualitative study
 Potentially useful method:
 Use appropriate MeSH terms in search:
 eg: qualitative research, focus groups, narration,
anecdotes, grounded theory, attitude, knowledge,
practice
 Limit search to publication types
 Use a Quality research filter
 Pubmed Health services research queries
 http://www.nlm.nih.gov/nichsr/hedges/search.html
Finding Qualitative Research Articles: Pubmed . http://libguides.hsl.washington.edu/c.php?g=99112&p=642322
Thank you
Any Questions?

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