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DEPARTMENT OF PHARMACOLOGY
FACULTY OF PHARMACY
CAIRO UNIVERSITY
NUMBERS 40684-40700 1
 5-Fluorouracil is a uracil with a stable fluorine atom
at position 5
 When inside the cell, its converted to the
corresponding deoxynucleotide (5-fluro-
deoxyuridine monophosphate [5-FdUMP])
2
 A 2 years old male was admitted to 57357
hospital with non metastatic
hepatoblastoma
 Associated Diagnosis: None.
 Fair General condition and Huge hepatic
mass.
3
Treatment Day II
CT scanning of the pelvis and the abdomen:
Mild hepatomegaly.
The main portal vein is patent.
4
CBC
5
 Due to bone marrow suppression, there
is notable:
Neutropenia.
Thrombocytopenia.
6
NAUSEA
VOMITING DIARRHOEA
Other associated side effects
7
Stomatitis and irritation of
the GI mucosa.
8
The hand-foot syndrome
CHARACTERIZED BY REDDENING,
SWELLING, NUMBNESS AND
DESQUAMATION OF THE SKIN.
9
Other unreported side effects
 CARDIOTOXICITY ( ARRHYTHMIA OR ANGINA ).
 NEPHROTOXICITY.
 BLURRED VISION.
10
 57357 HOSPITAL PHARMACY.
 LEXI.COM
 KATZUNG BASIC AND CLINICAL PHARMACOLOGY 12TH EDITIO
11
12

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