5 fu11
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5-Fluorouracil is converted inside cells to 5-fluro-deoxyuridine monophosphate which inhibits thymidylate synthase and disrupts DNA synthesis. A 2-year-old male was admitted to the hospital with non-metastatic hepatoblastoma and underwent CT scanning showing mild hepatomegaly and a patent portal vein. Due to bone marrow suppression from treatment, the patient experienced neutropenia, thrombocytopenia, nausea, vomiting, and diarrhea.
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![5-Fluorouracil is a uracil with a stable fluorine atom
at position 5
When inside the cell, its converted to the
corresponding deoxynucleotide (5-fluro-
deoxyuridine monophosphate [5-FdUMP])
2](https://image.slidesharecdn.com/5-fu11-130613192616-phpapp02/85/5-fu11-2-320.jpg)
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5 fu11
- 1. DEPARTMENT OF PHARMACOLOGY FACULTY OF PHARMACY CAIRO UNIVERSITY NUMBERS 40684-40700 1
- 2. 5-Fluorouracil is a uracil with a stable fluorine atom at position 5 When inside the cell, its converted to the corresponding deoxynucleotide (5-fluro- deoxyuridine monophosphate [5-FdUMP]) 2
- 3. A 2 years old male was admitted to 57357 hospital with non metastatic hepatoblastoma Associated Diagnosis: None. Fair General condition and Huge hepatic mass. 3
- 4. Treatment Day II CT scanning of the pelvis and the abdomen: Mild hepatomegaly. The main portal vein is patent. 4
- 5. CBC 5
- 6. Due to bone marrow suppression, there is notable: Neutropenia. Thrombocytopenia. 6
- 7. NAUSEA VOMITING DIARRHOEA Other associated side effects 7
- 8. Stomatitis and irritation of the GI mucosa. 8
- 9. The hand-foot syndrome CHARACTERIZED BY REDDENING, SWELLING, NUMBNESS AND DESQUAMATION OF THE SKIN. 9
- 10. Other unreported side effects CARDIOTOXICITY ( ARRHYTHMIA OR ANGINA ). NEPHROTOXICITY. BLURRED VISION. 10
- 11. 57357 HOSPITAL PHARMACY. LEXI.COM KATZUNG BASIC AND CLINICAL PHARMACOLOGY 12TH EDITIO 11
- 12. 12