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1. Biochemistry is the science concerned with the chemical basis of life and the chemical constituents of living cells and the reactions they undergo. 2. The aims of biochemistry are to describe and explain all the chemical processes of living cells at the molecular level, determine how life began, and gain a complete understanding of cellular processes. 3. Knowledge of biochemistry is essential to life sciences like immunology, physiology, pharmacology, pathology, and microbiology. The reciprocal relationship between biochemistry and medicine has stimulated advances in both fields.

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1 、 definition
• Science concerned with
chemical basis of life

3
• Science concerned with
the chemical constituents
of living cells and with the
reaction and process that
they undergo

4
2 、 The aim of
biochemistry
• Describe and explain in
molecular term
• All chemical process of
living cell

5
（ 1 ） major objective of
biochemistry
Complete understanding at
the molecular level of all the
chemical processes associated with
living cells

7
(2) Further objective
Attempt to understand
how life began

8
• An appreciation of the
biochemistry of less complex
form of life is often direct
relevance to human
biochemistry

9
3.knowledge of biochemistry is
essential to all life science

10
• immunology
•physiology
• pharmacology
• pathology
• microbiology

11
4 、 reciprocal relationship
between biochemistry &
medicine has stimulated
mutual advance

12
* Biochemistry studies have
illuminated many aspects of
health & disease
* the study of various aspects of
health & disease has opened up
new areas of biochemistry

13
biochemistry
Nucleic
acid
protein lipid Carbohydrates
Genetic
disease
Sickle cell
anemia
medicine
arteriosclerosis Diabetes
mellitus

14
5. Normal biochemical
processes are the basis
of health

15
Definition of health
“Complete physical,mental &
social well-being and not merely
the absence of disease and
infirmity”
------WHO

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• The situation in which all of the many
thousands of intra & extra cellular
reactions that occur in the body are
proceeding at the rates commensurate
with its maximal survival in the
physiological state
A strictly biochemistry viewpoint about health:

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6. Biochemical research has
impact on nutrition and
preventive medicine

18
7. all disease has a
biochemical basis

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(1)physical agent:
mechanical trauma,
extremes of temperature,
sudden changes in atmospheric
pressure,
radiation,
electric shock

20
(2)chemical agents:
drugs,
certain toxic compounds,
therapeutic drugs

21
(3)biologic agents:
Viruses,
Bacteria,
Fungi,
Higher forms of parasites

22
(4) oxygen lack
loss of blood supply,
depletion of the oxygen-carrying capacity
of the blood,
poisoning of the oxidative enzyme

23
(5) genetic disorders:
Congenital , molecular

24
(6) immunology reaction
Anaphylaxis,
Autoimmune disease

25
(7) nutritional imbalances
Deficiencies,excesses

26
(8) Endocrine imbalances
hormonal
deficiencies,excesses

27
8. Biochemical studies
contribute to
diagnosis, prognosis
& treatment

28
Disease causes
scurvy deficiencies of vitamin
rickets C,D respectively
Arteriosclerosis genetic,dietary
environment factors
Phenylketonuria mainly mutation in
the gene coding
phenylalanine hydroxylase

29
Disease causes
Cystic fibrosis mutation in the gene
coding the CFTR
protein
Cholera exotoxin of
vibrio cholera
Diabetes type I genetic and
environment factors resulting in
deficiency of insulin

30
9.many biochemical studies
illuminate disease
mechanisms & disease
inspire biochemical

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Use example
(1) to reveal the fundamental demonstration
causes &mechanisms of the genetic
of diseases defects in CF
(2) to suggest rational use of a diet low in
treatment of diseases phenylalanine
for the treatment of s
phenylketonuria(3) to assist in the diagnosis use of the plasma
of specific disease enzyme CK-MB in
the diagnosis of

32
Use example
(4) To act as screening use of measurement of
tests for the early blood tyrosine or
diagnosis of certain diseases TSH in the
neonatal diagnosis
of congenital
hypothyroidism

33
Use example
(5)To assist in monitoring use of the plasma enzyme
the progress of certain ALT in monitoring the
disease progress of infectious
hepatitis
(6) To assist in assessing the use of measurement of
response of diseases to therapy blood CEA in certain
patients who have
been treated for cancer
of the colon

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1. 1 Biochemistry & medicine introduction

2. 2 1 、 definition • Science concerned with chemical basis of life

3. 3 • Science concerned with the chemical constituents of living cells and with the reaction and process that they undergo

4. 4 2 、 The aim of biochemistry • Describe and explain in molecular term • All chemical process of living cell

5. 5 （ 1 ） major objective of biochemistry Complete understanding at the molecular level of all the chemical processes associated with living cells

6. 6 • determine • isolation • analyze

7. 7 (2) Further objective Attempt to understand how life began

8. 8 • An appreciation of the biochemistry of less complex form of life is often direct relevance to human biochemistry

9. 9 3.knowledge of biochemistry is essential to all life science

10. 10 • immunology •physiology • pharmacology • pathology • microbiology

11. 11 4 、 reciprocal relationship between biochemistry & medicine has stimulated mutual advance

12. 12 * Biochemistry studies have illuminated many aspects of health & disease * the study of various aspects of health & disease has opened up new areas of biochemistry

13. 13 biochemistry Nucleic acid protein lipid Carbohydrates Genetic disease Sickle cell anemia medicine arteriosclerosis Diabetes mellitus

14. 14 5. Normal biochemical processes are the basis of health

15. 15 Definition of health “Complete physical,mental & social well-being and not merely the absence of disease and infirmity” ------WHO

16. 16 • The situation in which all of the many thousands of intra & extra cellular reactions that occur in the body are proceeding at the rates commensurate with its maximal survival in the physiological state A strictly biochemistry viewpoint about health:

17. 17 6. Biochemical research has impact on nutrition and preventive medicine

18. 18 7. all disease has a biochemical basis

19. 19 (1)physical agent: mechanical trauma, extremes of temperature, sudden changes in atmospheric pressure, radiation, electric shock

20. 20 (2)chemical agents: drugs, certain toxic compounds, therapeutic drugs

21. 21 (3)biologic agents: Viruses, Bacteria, Fungi, Higher forms of parasites

22. 22 (4) oxygen lack loss of blood supply, depletion of the oxygen-carrying capacity of the blood, poisoning of the oxidative enzyme

23. 23 (5) genetic disorders: Congenital , molecular

24. 24 (6) immunology reaction Anaphylaxis, Autoimmune disease

25. 25 (7) nutritional imbalances Deficiencies,excesses

26. 26 (8) Endocrine imbalances hormonal deficiencies,excesses

27. 27 8. Biochemical studies contribute to diagnosis, prognosis & treatment

28. 28 Disease causes scurvy deficiencies of vitamin rickets C,D respectively Arteriosclerosis genetic,dietary environment factors Phenylketonuria mainly mutation in the gene coding phenylalanine hydroxylase

29. 29 Disease causes Cystic fibrosis mutation in the gene coding the CFTR protein Cholera exotoxin of vibrio cholera Diabetes type I genetic and environment factors resulting in deficiency of insulin

30. 30 9.many biochemical studies illuminate disease mechanisms & disease inspire biochemical

31. 31 Use example (1) to reveal the fundamental demonstration causes &mechanisms of the genetic of diseases defects in CF (2) to suggest rational use of a diet low in treatment of diseases phenylalanine for the treatment of s phenylketonuria(3) to assist in the diagnosis use of the plasma of specific disease enzyme CK-MB in the diagnosis of

32. 32 Use example (4) To act as screening use of measurement of tests for the early blood tyrosine or diagnosis of certain diseases TSH in the neonatal diagnosis of congenital hypothyroidism

33. 33 Use example (5)To assist in monitoring use of the plasma enzyme the progress of certain ALT in monitoring the disease progress of infectious hepatitis (6) To assist in assessing the use of measurement of response of diseases to therapy blood CEA in certain patients who have been treated for cancer of the colon

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