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Ergosterol
Prepared by
Dr. N.GOPINATHAN
ASSISTANT PROFESSOR
DEPARTMENT OF PHARMACEUTICAL CHEMISTRY
FACULTY OF PHARMACY
SRI RAMACHANDRA UNIVERSITY
CHENNAI-116
TAMILNADU
Structure
CH3
CH3
CH3CH3
CH3
CH3
OH
 C 28 sterol
 It is commonest mycosterol.
 It is precursor for Vit-D2
 The exposure of ergosterol to UV
gives ergocalciferol.
 It provides route to
progesterone and adrenocortical
harmone.
Conjugated diene system
 It undergoes Diels
alder reaction with
maleic anhydride to
give adduct.
Reduction partial-with sodium ethanol
gives dihydro derivative
CH3
CH3
CH3CH3
CH3
CH3
OH
CH3
CH3
CH3CH3
CH3
CH3
OH
Degradation
CH3
CH3
CH3CH3
CH3
CH3
OH
CH3
CH3
CH3
OH
O
CH3
CH3
CH3
OH
O
CH3
CH3
CH3
CH3
CH3
OH
O
Thank you

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