This document summarizes Mike Krieger's talk on scaling Instagram from its early days with 2 founders and no backend experience to supporting over 30 million users. Some key points include: using PostgreSQL with vertical and horizontal partitioning for the database; Redis for caching and real-time updates; focusing on simplicity, instrumentation, and operational ease over premature optimization; and staying nimble through frequent code reviews and monitoring. Krieger emphasizes scaling the system while maintaining its core functionality of fast, beautiful photo sharing.