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Molecular Mysteries of the Plant Periwinkle
Native to Madagascar
What is Ethnobotany?
Plants as Medicine?
Natural History
Worldwide Folk Remedies India China Central America South America Hawaii Jamaica
Rich in Chemical Properties
Alkaloids of Interest Vinblastine Vincristine Vindesine Vinorelbine
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Another Look
Pharmacology Vinblastine:  Hodgkins   disease, lymphomas, advanced cancers Vincristine:  leukemia, Hodgkins disease, lymphomas Vindesine:  melanoma, lung and uterine cancers Vinorelbine:  currently in clinical trials for ovarian cancer
How  do they work? Same basic action Inhibit Mitosis
Never Reaches Anaphase
Similar, but Different
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Into the Future
References www.accessexcellence.org www.biotech.icmb.utexas.edu www.botanical.com www.life.umd.edu www.ncbi.nlm.nih.gov www.prenhall.com/Brown9

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Molecular Mysteries Of The Plant Periwinkle