3. "Criteria for substance use dependence in ICD-10
Three or more of the following must have been experienced or
exhibited at some time during the previous year:
1.A strong desire or sense of compulsion to take the substance;
2.Difficulties in controlling substance-taking behaviour in terms of its
onset, termination, or levels of use;
3.A physiological withdrawal state when substance use has ceased or
been reduced, as evidenced by: the characteristic withdrawal
syndrome for the substance; or use of the same (or a closely related)
substance with the intention of relieving or avoiding withdrawal
symptoms;
4.Evidence of tolerance, such that increased doses of the
psychoactive substance are required in order to achieve effects
originally produced by lower doses;
5.Progressive neglect of alternative pleasures or interests because of
psychoactive substance use, increased amount of time necessary to
obtain or take the substance or to recover from its effects ;
6.Persisting with substance use despite clear evidence of overtly
harmful consequences, such as harm to the liver through excessive
drinking, depressive mood states consequent to heavy substance
use, or substance-related impairment of cognitive functioning. Efforts
should be made to determine that the user was actually, or could be
expected to be, aware of the nature and extent of the harm.