aerosols.pptx

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The document discusses the materials used in manufacturing aerosol containers. It describes the different types of containers - tinplate steel, aluminum, stainless steel, and glass. Tinplate steel containers are the most commonly used type and are made by electroplating tin on steel sheets that are cut and assembled. Aluminum containers provide greater corrosion resistance but can be corroded by pure water and ethanol. Stainless steel containers are very strong but limited to smaller sizes. Glass containers are used for some pharmaceutical aerosols. The document also discusses valve assemblies and the inert materials like plastic, rubber, aluminum, and stainless steel that are approved for use.

Health & Medicine

Presented by Danish Yousuf
Roll.No. 18054110021
B.Pharm 4th year
Department of pharmaceutical sciences
University of kashmir

 Pressurised dosage form that
upon actuation emit a fine
dispersion of liquid and/or solid
material containing one or more
active ingredents in gaseous
med.

 Materials indicated in manufacture of aerosol
continers –must with stand pressure as high as
140 -180 psig at 130º F
#psig=pounds per sq. inch gauge.
 Tinplate container
 Aluminum container
 Stainless steel container
 Glass container

 Tinplated steel- sheet of steel plate that has
been electroplated on b/s with tin .
 Coated sheet is cut into three pieces
(top,bottom and body)
 The top, bottom are attached to body by
soldering.
 When requires coated with organic material
(oleoresin ,phenolic ,vinyl or epoxy coating)
 Welding eliminates soldering process ,saves
manufacturing time and decreases product-
container interactions.

 Used for inhalation and topical aerosols.
 Used to manufacture seamless aerosol
container – less incompatibility due to seamless
nature.
 Al greater resistance to corrosion.
 However corroded by pure water and pure
ethanol.
 Ehanol-propellant 11_hydrogen,acetyl
chloride,aluminium chloride, propellant 21 and
other corrosive products.

 These containers are limited to smaller sizes-
owing to production problems as well as cost.
 Extremely strong and resistant to most
materials.
 Used for inhalation aerosols.
 Most cases no internal coating req.

 Used for large no. of aerosols pharmaceuticals.
 Available with or without plastic coating.
 Preferred because of absence of
incompatibilities.
 Limited to products having lower pressure (33
psig) and lower %age of the propellant.
 Used for topical and MDI aerosols.
 Two types
1. Uncoated
2 Plastic coated .

 Fun. Of valve assembly is to premit expulsion
of contents of the can in the desired form,rate
and in case of metered valves,in proper amount
or dose.
 Material used should be inert to formulation &
must be app. by FDA .
 Materials used-Plastic ,rubber,Al and stainless
steel.

 Actuator (Plastic)
 Stem (Plastic)
 Gasket (rubber or plastic )
 Spring (metal)
 Mounting cup (METAL)
 Housing (Plastic)
 Dip tube (Plastic)

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aerosols.pptx

1. Presented by Danish Yousuf Roll.No. 18054110021 B.Pharm 4th year Department of pharmaceutical sciences University of kashmir

2.  Pressurised dosage form that upon actuation emit a fine dispersion of liquid and/or solid material containing one or more active ingredents in gaseous med.

4.  Materials indicated in manufacture of aerosol continers –must with stand pressure as high as 140 -180 psig at 130º F #psig=pounds per sq. inch gauge.  Tinplate container  Aluminum container  Stainless steel container  Glass container

5.  Tinplated steel- sheet of steel plate that has been electroplated on b/s with tin .  Coated sheet is cut into three pieces (top,bottom and body)  The top, bottom are attached to body by soldering.  When requires coated with organic material (oleoresin ,phenolic ,vinyl or epoxy coating)  Welding eliminates soldering process ,saves manufacturing time and decreases product- container interactions.

6.  Used for inhalation and topical aerosols.  Used to manufacture seamless aerosol container – less incompatibility due to seamless nature.  Al greater resistance to corrosion.  However corroded by pure water and pure ethanol.  Ehanol-propellant 11_hydrogen,acetyl chloride,aluminium chloride, propellant 21 and other corrosive products.

7.  These containers are limited to smaller sizes- owing to production problems as well as cost.  Extremely strong and resistant to most materials.  Used for inhalation aerosols.  Most cases no internal coating req.

8.  Used for large no. of aerosols pharmaceuticals.  Available with or without plastic coating.  Preferred because of absence of incompatibilities.  Limited to products having lower pressure (33 psig) and lower %age of the propellant.  Used for topical and MDI aerosols.  Two types 1. Uncoated 2 Plastic coated .

9.  Fun. Of valve assembly is to premit expulsion of contents of the can in the desired form,rate and in case of metered valves,in proper amount or dose.  Material used should be inert to formulation & must be app. by FDA .  Materials used-Plastic ,rubber,Al and stainless steel.

10.  Actuator (Plastic)  Stem (Plastic)  Gasket (rubber or plastic )  Spring (metal)  Mounting cup (METAL)  Housing (Plastic)  Dip tube (Plastic)

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