One Step Clinic is a leading outpatient addiction treatment facility in Ireland. For suitable patients Naltrexone implants are administered as part of a sustained treatment option.
Naltrexone Implants for Treatment of AddictionSCGH ED CME
油
The document summarizes information about naltrexone implants used for opioid and methamphetamine dependence treatment. It describes a case of severe opioid withdrawal in a patient who received a naltrexone implant that morning. Key points include:
- Naltrexone is an opioid receptor antagonist that blocks the effects of opioids for up to 24 hours after a single dose. Implants release naltrexone over months.
- Patients undergoing rapid detox with naltrexone implants are at risk of severe withdrawal symptoms like agitation and vomiting within hours of the implant.
- Management of withdrawal includes sedation, anti-emetics, clonidine, and monitoring for complications like respiratory depression.
This document outlines topics related to general principles of pharmacology including: drugs that affect the nervous, respiratory, and cardiovascular systems; electrolytes; drugs used to treat myocardial infarction and allergic reactions; and drugs that affect the endocrine system. It provides information on specific medications for each topic, including their classifications, indications, and mechanisms of action.
The document discusses various types of interferences that can occur in clinical chemistry analysis, including hemolysis, lipemia, and icterus. Hemolysis occurs when red blood cells rupture, releasing intracellular components into plasma and affecting test results. Lipemia is the presence of fatty substances in blood from high triglyceride levels, interfering with light transmission. Icterus is yellowing from increased bilirubin, which absorbs light and acts as a chemical interferant. These interferences can lead to incorrect test results and diagnoses if not properly identified and accounted for.
Pharmacology of Cholinergic Drugs. It contains a detailed elaboration of Cholinergic Agents, Cholinomimmetics, Cholinergic Antagonists, Synthesis of Ach, Receptors, Classification, Mechanism of Action, Pharmacokinetics and Dynamics, Dosage and Adverse effects
Cholinergic+antagonists+by+pharma+raptorsAniket Kale
油
The document summarizes antimuscarinic drugs. It discusses their mechanism of action as competitive antagonists that block acetylcholine at muscarinic receptors. It classifies antimuscarinics into quaternary and tertiary amines based on their ability to cross the blood-brain barrier. The therapeutic uses include pupil dilation, treatment of asthma, peptic ulcer, and Parkinson's disease. Four categories of antimuscarinics are outlined - solanaceous alkaloids, amino alcohols, amino alcohol esters, and amino ethers. Examples like atropine and ipratropium bromide are described along with their structures, properties, and uses.
Classification and analysis of narcoticsJunaidChemist
油
narcotics are the analgesic agents that reduce the sensation. On the basis of there origin, narcotics are classified into three major groups. They can be analyzed with the help of HPLC-MS system.
This document provides an overview of steroids and opioids. It defines steroids and classifies them into glucocorticoids, mineralocorticoids, androgens, and others. It discusses the dosing, mode of action, clinical uses and side effects of steroids. The document also defines opioids and classifies them into endogenous, exogenous, and synthetic opioids. It describes the mechanisms of action, tolerance, clinical uses and examples of commonly used opioids like morphine, pethidine, tramadol, heroin, and fentanyl. The document concludes by discussing opioid antagonists like naloxone.
Local anesthesia is the most widely used method of pain control in dental practice. It involves injecting local anesthetic drugs near nerves to reversibly block nerve conduction and sensation in a specific part of the body. The first local anesthetic used was cocaine, extracted in 1859. Modern local anesthetics like lidocaine and bupivacaine reversibly block sodium channels, preventing nerve impulse propagation. They are metabolized in the liver and may cause minor complications like pain on injection or transient numbness, but rarely major issues. Proper dosage and technique help ensure safe and effective local anesthesia for dental procedures.
Local Ocular Anesthetics Used in Ophthalmic ClinicsGauriSShrestha
油
This document provides information on local anesthetics (LAs) that are used in ophthalmic practice. It discusses the mechanisms of action, classifications, and comparisons of different LAs. It also covers indications, contraindications, and techniques for ocular anesthesia. The key points are:
- LAs reversibly block nerve impulse transmission along sensory fibers. Common ophthalmic LAs include lidocaine, bupivacaine, tetracaine, and oxybuprocaine.
- Amide-linked LAs like lidocaine are more stable, have longer duration of action, and cause less hypersensitivity than ester-linked LAs.
- Indications for ocular anesthesia include
This document provides an overview of local anesthesia. It begins with definitions and a brief history of local anesthesia from 1844 to present. It then classifies local anesthetics based on their origin, chemical structure, and duration of action. The document discusses the composition of local anesthetics including the local anesthetic agent, vasoconstrictor, preservative, and other components. It also covers the theories of action, mechanisms of action, techniques for maxillary and mandibular anesthesia, as well as the indications, contraindications, advantages and disadvantages of local anesthesia. Specific local anesthetic agents such as lidocaine, mepivacaine, prilocaine, articaine, bupivacaine and etidocaine
This document provides an overview of a lecture on pain, local anesthetics, and general anesthetics. It begins with learning objectives on local anesthetics, their mechanisms of action, side effects, and commonly used agents. It then covers learning objectives on general anesthetics, including definitions, pharmacokinetics, stages of anesthesia, and commonly used inhaled and intravenous agents. The document discusses pain pathways and mechanisms of local anesthetics. It also provides classifications of local and general anesthetic agents and covers principles of general anesthesia, including objectives, mechanisms of action, and factors to consider when selecting anesthetics.
1) The presentation discusses the pharmacology and mechanisms of action of inhalational anesthetic agents. It covers topics like pharmacokinetics, theories of anesthetic action including lipid solubility and protein-based theories, measures of potency like MAC, and factors affecting uptake and distribution.
2) Several outdated and modern theories attempt to explain how general anesthetics produce immobility, amnesia, and analgesia by modulating neuronal membrane proteins, but the exact mechanisms are still largely unknown.
3) Inhalational agents are thought to act through multiple molecular targets in both the spinal cord and brain to produce their diverse effects.
This document discusses local anaesthetic agents. It defines local anaesthetics as compounds that produce temporary neural blockade. It describes the history of local anaesthetics from cocaine in the 19th century to modern synthetic derivatives. It outlines the ideal properties of local anaesthetics and classifications such as ester vs amide groups and duration of action. The document discusses the structure, mechanisms of action, pharmacokinetics, toxicity and management of toxicity of local anaesthetic agents. It also covers adjuvants that are added to local anaesthetics to modify their effects.
Local anesthetics work by reversibly blocking sodium channels in nerve cell membranes, preventing the propagation of action potentials and sensation. They are useful for minor procedures as they cause loss of sensation in a localized area without loss of consciousness. Common local anesthetics include lidocaine, bupivacaine, and procaine. Factors like lipid solubility and pH influence their onset and duration of action. While generally safe, local anesthetics can potentially cause adverse effects like numbness, seizures, or cardiac issues depending on the drug and dosage. Proper technique and patient health assessment are important considerations for safe use of local anesthesia.
General anesthetics cause reversible loss of consciousness and perception during surgery by depressing the central nervous system. They provide analgesia, amnesia, muscle relaxation and unconsciousness. Common inhalational anesthetics include halothane, isoflurane and sevoflurane. Pre-anesthetic medications are often administered to relieve anxiety, provide amnesia and reduce anesthetic requirements. Inhalational anesthetics are delivered via open or closed systems and their effects are determined by factors like potency, solubility and metabolism. Their mechanism of action involves actions on ion channels and receptors in the brain.
This document discusses various drugs and their dependence liability. It describes how dependence develops from repeated drug administration and involves tolerance, physical withdrawal, and psychological craving. Different classes of drugs are listed with their typical dependence liability, from very strong for narcotics to weak or absent for LSD and cannabis. The mechanisms, effects, metabolism, and treatment approaches are summarized for several specific drugs, including nicotine, ethanol, cannabis, LSD, and cocaine.
This document discusses the pharmacology of local anesthesia. It describes the constituents of local anesthetic cartridges which include the local anesthetic agent, vasoconstrictor, preservative, and vehicle. It discusses the properties of ideal anesthetic agents and the common properties of injectable local anesthetics. The document outlines the mode of action, pharmacokinetics including uptake, potency, duration, biotransformation, and excretion of local anesthetics. It provides details on ester and amide local anesthetic drugs as well as vasoconstrictor agents.
This document outlines a course module for Pharmaceutical Chemistry-VII. The module will cover synthesis, properties, and uses of various drug classes over 36 lectures and practical sessions. Key classes discussed include steroids, central nervous system drugs, cardiovascular drugs, and diuretics. Students will learn synthesis techniques, spectral analysis, and pharmacopoeial standards. Assessment includes assignments, presentations, tests, and practical work. Textbooks and topics for additional study are also listed.
local anesthesia: Uses, Types, Side effects and SafetyPrachiRathi40
油
This document provides an overview of local anesthesia. It begins with definitions and an introduction. It then covers the historical background, classifications, components, mechanisms of action, techniques, and complications of local anesthesia. The classifications section divides local anesthetics based on their pharmacology, route of administration, biologic site and mode of action, and duration of action. Key local anesthetic agents like lidocaine, mepivacaine, articaine, bupivacaine, and topical anesthetics are also summarized. Maximum recommended doses and specific nerve block techniques for the maxillary nerve are outlined. In conclusion, the document reviews local anesthesia in detail.
A good read for undergraduate students in Pharmacy studying at the University of Mumbai. I will highly recommend Essentials of Medical Pharmacology by KD Tripathi. All copyright to the original authors and publishers.
This document discusses the pharmacology of several intravenous anesthetics used for general anesthesia induction and maintenance. It provides a brief history of intravenous anesthetics and covers the pharmacokinetic properties and organ system effects of thiopental, benzodiazepines like midazolam, opioids, ketamine, etomidate, and propofol. For each drug, the document discusses mechanisms of action, distribution, metabolism and elimination, and clinical applications.
Introduction to Pharmacology.pptx ppttttSoravSorout
油
Pharmacology is the study of drugs, including what they do in the body, how they act, their uses and adverse effects. Throughout history, people have used plants and other substances to treat illnesses, and modern pharmacology developed through experimentation and clinical trials. Pharmacology involves understanding how drugs are absorbed, distributed, and eliminated from the body as well as their effects, mechanisms of action, and interactions with receptors and other proteins in the body.
The cornea can recover from minor injuries on its own. If it is scratched, healthy cells slide over quickly and patch the injury before it causes infection or affects vision. But if a scratch causes a deep injury to the cornea, it will take longer to heal.
There are seven extraocular muscles the levator palpebrae superioris, superior rectus, inferior rectus, medial rectus, lateral rectus, inferior oblique and superior oblique. Functionally, they can be divided into two groups: Responsible for eye movement Recti and oblique muscles.
Local anesthesia is the most widely used method of pain control in dental practice. It involves injecting local anesthetic drugs near nerves to reversibly block nerve conduction and sensation in a specific part of the body. The first local anesthetic used was cocaine, extracted in 1859. Modern local anesthetics like lidocaine and bupivacaine reversibly block sodium channels, preventing nerve impulse propagation. They are metabolized in the liver and may cause minor complications like pain on injection or transient numbness, but rarely major issues. Proper dosage and technique help ensure safe and effective local anesthesia for dental procedures.
Local Ocular Anesthetics Used in Ophthalmic ClinicsGauriSShrestha
油
This document provides information on local anesthetics (LAs) that are used in ophthalmic practice. It discusses the mechanisms of action, classifications, and comparisons of different LAs. It also covers indications, contraindications, and techniques for ocular anesthesia. The key points are:
- LAs reversibly block nerve impulse transmission along sensory fibers. Common ophthalmic LAs include lidocaine, bupivacaine, tetracaine, and oxybuprocaine.
- Amide-linked LAs like lidocaine are more stable, have longer duration of action, and cause less hypersensitivity than ester-linked LAs.
- Indications for ocular anesthesia include
This document provides an overview of local anesthesia. It begins with definitions and a brief history of local anesthesia from 1844 to present. It then classifies local anesthetics based on their origin, chemical structure, and duration of action. The document discusses the composition of local anesthetics including the local anesthetic agent, vasoconstrictor, preservative, and other components. It also covers the theories of action, mechanisms of action, techniques for maxillary and mandibular anesthesia, as well as the indications, contraindications, advantages and disadvantages of local anesthesia. Specific local anesthetic agents such as lidocaine, mepivacaine, prilocaine, articaine, bupivacaine and etidocaine
This document provides an overview of a lecture on pain, local anesthetics, and general anesthetics. It begins with learning objectives on local anesthetics, their mechanisms of action, side effects, and commonly used agents. It then covers learning objectives on general anesthetics, including definitions, pharmacokinetics, stages of anesthesia, and commonly used inhaled and intravenous agents. The document discusses pain pathways and mechanisms of local anesthetics. It also provides classifications of local and general anesthetic agents and covers principles of general anesthesia, including objectives, mechanisms of action, and factors to consider when selecting anesthetics.
1) The presentation discusses the pharmacology and mechanisms of action of inhalational anesthetic agents. It covers topics like pharmacokinetics, theories of anesthetic action including lipid solubility and protein-based theories, measures of potency like MAC, and factors affecting uptake and distribution.
2) Several outdated and modern theories attempt to explain how general anesthetics produce immobility, amnesia, and analgesia by modulating neuronal membrane proteins, but the exact mechanisms are still largely unknown.
3) Inhalational agents are thought to act through multiple molecular targets in both the spinal cord and brain to produce their diverse effects.
This document discusses local anaesthetic agents. It defines local anaesthetics as compounds that produce temporary neural blockade. It describes the history of local anaesthetics from cocaine in the 19th century to modern synthetic derivatives. It outlines the ideal properties of local anaesthetics and classifications such as ester vs amide groups and duration of action. The document discusses the structure, mechanisms of action, pharmacokinetics, toxicity and management of toxicity of local anaesthetic agents. It also covers adjuvants that are added to local anaesthetics to modify their effects.
Local anesthetics work by reversibly blocking sodium channels in nerve cell membranes, preventing the propagation of action potentials and sensation. They are useful for minor procedures as they cause loss of sensation in a localized area without loss of consciousness. Common local anesthetics include lidocaine, bupivacaine, and procaine. Factors like lipid solubility and pH influence their onset and duration of action. While generally safe, local anesthetics can potentially cause adverse effects like numbness, seizures, or cardiac issues depending on the drug and dosage. Proper technique and patient health assessment are important considerations for safe use of local anesthesia.
General anesthetics cause reversible loss of consciousness and perception during surgery by depressing the central nervous system. They provide analgesia, amnesia, muscle relaxation and unconsciousness. Common inhalational anesthetics include halothane, isoflurane and sevoflurane. Pre-anesthetic medications are often administered to relieve anxiety, provide amnesia and reduce anesthetic requirements. Inhalational anesthetics are delivered via open or closed systems and their effects are determined by factors like potency, solubility and metabolism. Their mechanism of action involves actions on ion channels and receptors in the brain.
This document discusses various drugs and their dependence liability. It describes how dependence develops from repeated drug administration and involves tolerance, physical withdrawal, and psychological craving. Different classes of drugs are listed with their typical dependence liability, from very strong for narcotics to weak or absent for LSD and cannabis. The mechanisms, effects, metabolism, and treatment approaches are summarized for several specific drugs, including nicotine, ethanol, cannabis, LSD, and cocaine.
This document discusses the pharmacology of local anesthesia. It describes the constituents of local anesthetic cartridges which include the local anesthetic agent, vasoconstrictor, preservative, and vehicle. It discusses the properties of ideal anesthetic agents and the common properties of injectable local anesthetics. The document outlines the mode of action, pharmacokinetics including uptake, potency, duration, biotransformation, and excretion of local anesthetics. It provides details on ester and amide local anesthetic drugs as well as vasoconstrictor agents.
This document outlines a course module for Pharmaceutical Chemistry-VII. The module will cover synthesis, properties, and uses of various drug classes over 36 lectures and practical sessions. Key classes discussed include steroids, central nervous system drugs, cardiovascular drugs, and diuretics. Students will learn synthesis techniques, spectral analysis, and pharmacopoeial standards. Assessment includes assignments, presentations, tests, and practical work. Textbooks and topics for additional study are also listed.
local anesthesia: Uses, Types, Side effects and SafetyPrachiRathi40
油
This document provides an overview of local anesthesia. It begins with definitions and an introduction. It then covers the historical background, classifications, components, mechanisms of action, techniques, and complications of local anesthesia. The classifications section divides local anesthetics based on their pharmacology, route of administration, biologic site and mode of action, and duration of action. Key local anesthetic agents like lidocaine, mepivacaine, articaine, bupivacaine, and topical anesthetics are also summarized. Maximum recommended doses and specific nerve block techniques for the maxillary nerve are outlined. In conclusion, the document reviews local anesthesia in detail.
A good read for undergraduate students in Pharmacy studying at the University of Mumbai. I will highly recommend Essentials of Medical Pharmacology by KD Tripathi. All copyright to the original authors and publishers.
This document discusses the pharmacology of several intravenous anesthetics used for general anesthesia induction and maintenance. It provides a brief history of intravenous anesthetics and covers the pharmacokinetic properties and organ system effects of thiopental, benzodiazepines like midazolam, opioids, ketamine, etomidate, and propofol. For each drug, the document discusses mechanisms of action, distribution, metabolism and elimination, and clinical applications.
Introduction to Pharmacology.pptx ppttttSoravSorout
油
Pharmacology is the study of drugs, including what they do in the body, how they act, their uses and adverse effects. Throughout history, people have used plants and other substances to treat illnesses, and modern pharmacology developed through experimentation and clinical trials. Pharmacology involves understanding how drugs are absorbed, distributed, and eliminated from the body as well as their effects, mechanisms of action, and interactions with receptors and other proteins in the body.
The cornea can recover from minor injuries on its own. If it is scratched, healthy cells slide over quickly and patch the injury before it causes infection or affects vision. But if a scratch causes a deep injury to the cornea, it will take longer to heal.
There are seven extraocular muscles the levator palpebrae superioris, superior rectus, inferior rectus, medial rectus, lateral rectus, inferior oblique and superior oblique. Functionally, they can be divided into two groups: Responsible for eye movement Recti and oblique muscles.
Reinforcement theory proposes that behaviors followed by positive consequences will be repeated, while behaviors followed by negative consequences will not. The document outlines four methods of controlling behavior according to reinforcement theory: positive reinforcement uses rewards to increase positive behavior; negative reinforcement reduces negative consequences to increase desired behavior; punishment applies undesirable consequences to achieve desired behavior; and extinction withholds reinforcement to reduce unwanted behavior. Organizations apply reinforcement management to increase productivity, reduce absenteeism, improve safety, and decrease injuries.
Incidence (Epidemiology lecture)
short ppt to understand incidence. primary incidence rate, secondary incidence rate, incidence rate, examples of incidence, incidence rate related question are discussed in this lec.
Color vision is very important for human eyes. all details about color vision, definition, classification, abnormalities and color vision test details are given in slides
This document discusses under 5 mortality rates, child mortality rates, and adult mortality rates for both females and males in Pakistan compared to worldwide rates. It is broken into sections covering under 5 mortality, child mortality, female adult mortality, male adult mortality, and overall adult mortality, with Pakistan rates compared to global rates in each section.
Optometry instruments is a presentation to describe instrument in a beautiful way. use this tool to improve your knowledge. stay blessed. Regards Muhammad Akbar Rashid Qadri.
This document provides an overview of SWOT analysis, a tool used to evaluate an organization's strengths, weaknesses, opportunities, and threats. It explains that SWOT analysis involves assessing internal strengths and weaknesses as well as external opportunities and threats. The document also outlines how to conduct a SWOT analysis by identifying key questions to consider for each component of the SWOT framework. These include evaluating competitive advantages, areas for improvement, trends in the operating environment, and potential obstacles. The overall purpose of SWOT analysis is to help craft a strategic plan by distinguishing an organization's position relative to competitors.
Burckner test or Red reflex test to check media opacities, and refractive error, we can also check deviations like esotropia exotropia with burckner test
This is a short presentation of scarring of wounds. Do not use this presentation or you complete information. you can only use this presentation information for recalling of your knowledge. This pdf file has important information about scarring of wounds and their healing process.
We need your suggestions about this topic. thank you so much.
Inventory Reporting in Odoo 17 - Odoo 17 Inventory AppCeline George
油
This slide will helps us to efficiently create detailed reports of different records defined in its modules, both analytical and quantitative, with Odoo 17 ERP.
How to create security group category in Odoo 17Celine George
油
This slide will represent the creation of security group category in odoo 17. Security groups are essential for managing user access and permissions across different modules. Creating a security group category helps to organize related user groups and streamline permission settings within a specific module or functionality.
Dr. Ansari Khurshid Ahmed- Factors affecting Validity of a Test.pptxKhurshid Ahmed Ansari
油
Validity is an important characteristic of a test. A test having low validity is of little use. Validity is the accuracy with which a test measures whatever it is supposed to measure. Validity can be low, moderate or high. There are many factors which affect the validity of a test. If these factors are controlled, then the validity of the test can be maintained to a high level. In the power point presentation, factors affecting validity are discussed with the help of concrete examples.
Hannah Borhan and Pietro Gagliardi OECD present 'From classroom to community ...EduSkills OECD
油
Hannah Borhan, Research Assistant, OECD Education and Skills Directorate and Pietro Gagliardi, Policy Analyst, OECD Public Governance Directorate present at the OECD webinar 'From classroom to community engagement: Promoting active citizenship among young people" on 25 February 2025. You can find the recording of the webinar on the website https://oecdedutoday.com/webinars/
How to Configure Proforma Invoice in Odoo 18 SalesCeline George
油
In this slide, well discuss on how to configure proforma invoice in Odoo 18 Sales module. A proforma invoice is a preliminary invoice that serves as a commercial document issued by a seller to a buyer.
How to Configure Deliver Content by Email in Odoo 18 SalesCeline George
油
In this slide, well discuss on how to configure proforma invoice in Odoo 18 Sales module. A proforma invoice is a preliminary invoice that serves as a commercial document issued by a seller to a buyer.
Comprehensive Guide to Antibiotics & Beta-Lactam Antibiotics.pptxSamruddhi Khonde
油
Comprehensive Guide to Antibiotics & Beta-Lactam Antibiotics
Antibiotics have revolutionized medicine, playing a crucial role in combating bacterial infections. Among them, Beta-Lactam antibiotics remain the most widely used class due to their effectiveness against Gram-positive and Gram-negative bacteria. This guide provides a detailed overview of their history, classification, chemical structures, mode of action, resistance mechanisms, SAR, and clinical applications.
What Youll Learn in This Presentation
History & Evolution of Antibiotics
Cell Wall Structure of Gram-Positive & Gram-Negative Bacteria
Beta-Lactam Antibiotics: Classification & Subtypes
Penicillins, Cephalosporins, Carbapenems & Monobactams
Mode of Action (MOA) & Structure-Activity Relationship (SAR)
Beta-Lactamase Inhibitors & Resistance Mechanisms
Clinical Applications & Challenges.
Why You Should Check This Out?
Essential for pharmacy, medical & life sciences students.
Provides insights into antibiotic resistance & pharmaceutical trends.
Useful for healthcare professionals & researchers in drug discovery.
Swipe through & explore the world of antibiotics today!
Like, Share & Follow for more in-depth pharma insights!
2. Aims and objective;
What are anesthetics drugs?
What are their composition?
What are their types?
what are their mechanism?
Ophthalmic uses
Adverse reaction
Question answer section?
6. Mechanism of action
Exact mechanism of action is
unknown but they show their
action by;
Prevent nerve generation
Prevent the nerve conduction
Slow nerve propagation
7. Onset of Action
It depend upon;
lipid solubility
PH of solution
Protein binding
Molecular size
Dissociation constant