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Anslag jonas

Jonas Ludvigsson
Jonas Ludvigsson
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Att s旦ka anslag eller... Svagheter i NIH-ans旦kningar
Kort presentation Barnl辰kare i Forskningsintresse: 1) gastroenterologi 2) nutrition lskar guideb旦cker Fotbollsfan (Barca vinner El Clasico...) Pappa till Hannes, Elias och Josef (HEJ)
Varf旦r s旦ka anslag?
Att hitta n奪got nytt F奪 m旦jlighet att syssla med n奪got ut旦ver kliniken Disputationen Man kan alltid resa p奪 en trevlig kongress... F旦rsta publicerade artikeln
Speci鍖ka syften / hypoteser Bakgrund / betydelse Pilot studie / prelimin辰ra resultat Inklusions- och exklusionskriterier Utfallsvariabler (outcome) Potentiella confounders (st旦rfaktorer)
Huvudbudskap I
Tidsplan
Huvudbudskap II
The devil is in the detail
Och om du vill g旦ra dig f旦rst奪dd...
Svagheter i NIH-ans旦kningar Get started
Speci鍖ka syften/hypoteser Background/signi鍖cance Pilot study Inclusion and inclusion criteria Outcome measures Potential confounders
Speci鍖ka syften I This study aims to examine the prevalence of celiac disease in those thought most at risk: XX (Speci鍖c aim number 1). verambiti旦sa m奪l D奪lig fokusering We aim to study whether the HLA associations seen in European Ingen klar hypotes populations are unaltered by the more heterogenous population of the US. (Speci鍖c aim number 2).
Speci鍖ka syften II Speci鍖c aim: 1. To measure the direct health care costs of the IL-1 treatment, as compared with gluten-free diet. 2. XX Syftet f旦ljs av en tydlig The associated hypotheses are: hypotes Hypothesis 1a: In the short term, the IL-1 treatment may result in increased costs compared with gluten-free diet Hypothesis 1b: In the long term, ....
Speci鍖c aims/hypothesis Bakgrund/betydelse Pilotstudie Inclusion and inclusion criteria Outcome measures Potential confounders Estimates of attrition rates
Bakgrund/betydelse To assess the role of breastfeeding in the etiological pathway of celiac disease is a task of high priority Betona betydelsen We wish to underline that this study can probably only be carried out in Sweden due to the Begr辰nsa bakgrunden existence of the Swedish Personal Identity Number... verdriv inte betydelsen XXXX Therefore, we believe this research av din studie can provide new information on the interplay between early nutrition and in鍖ammation in the young child.
Bakgrund/betydelse These studies provide the important background of... Betona betydelsen The current project will build on previous research... Begr辰nsa bakgrunden verdriv inte betydelsen Earlier research is limited by its dependence on...
Celiaki Man kan inte g辰rna h辰vda att celiaki 辰r ett st旦rre h辰lsoproblem 辰n cancer.... Men 辰r sjukdomen vanlig / drabbar m奪nga?
Speci鍖c aims/hypothesis Background/signi鍖cance Pilotstudie / prelimin辰ra resultat Inclusion and inclusion criteria Outcome measures Potential confounders
Inte min f旦rsta ans旦kan Nej Nej Nej Nej Nej Nej Nej Nej Prelimin辰ra resultat Ja!
Pilotstudie Relevant erfarenhet Tillr辰ckligt m奪nga deltagare? Testat inklusionen av deltagare?
Speci鍖c aims/hypothesis Background/signi鍖cance Pilot study Inklusions- och exklusionskriterier Outcome measures Potential confounders
Inklusionskriterier I lder K旦n Studieperiod Geogra鍖skt omr奪de Och gl旦m inte F旦delseland exklusionskriterierna! R旦kare/icke-r旦kare
Inklusionskriterier II Goda sk辰l att anv辰nda en viss datak辰lla Risk att studiedeltagarna oftare 辰r Studien b旦r inte vara r旦kare 辰n icke-r旦kare? biased eller icke- representativ! Studiedeltagarna 辰r ovanligt f旦ljsamma? Studiedeltagarna 辰r friskare/ sjukare 辰n genomsnittsinv奪naren? Strikta inklusionskriterier: f辰rre studiedeltagare?
Speci鍖c aims/hypothesis Background/signi鍖cance Pilot study Inclusion and exclusion criteria Utfallsvariabler (Outcome) Potential confounders
Utfall I Blindad utv辰rderare i randomiserade pr旦vningar Courtesy Wikipedia
Utfall II De鍖nition? N辰r har n奪gon + angina pectoris? + Courtesy Wikipedia
Utfall III Diabetes No Diabetes Surveillance bias? (旦vervakningsbias) Courtesy Wikipedia
Utfall IV Internationella de鍖nitioner? (du kanske vill publicera dina fynd?) 3 ggr / veckan Courtesy Wikipedia
Speci鍖c aims/hypothesis Background/signi鍖cance Pilot study Inclusion and exclusion criteria Outcome measures Potentiella confounders /st旦rfaktorer
Confounding Inouye and Fiellin 2005 Medicin mot H旦ft fraktur demens lder
Sammanfattning Var tydlig Prelimin辰ra resultat De鍖niera utfallet Inklusionskriterier Ta h辰nsyn till confounding
The End

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Anslag jonas

  • 2. Kort presentation Barnl辰kare i Forskningsintresse: 1) gastroenterologi 2) nutrition lskar guideb旦cker Fotbollsfan (Barca vinner El Clasico...) Pappa till Hannes, Elias och Josef (HEJ)
  • 4. Att hitta n奪got nytt F奪 m旦jlighet att syssla med n奪got ut旦ver kliniken Disputationen Man kan alltid resa p奪 en trevlig kongress... F旦rsta publicerade artikeln
  • 5. Speci鍖ka syften / hypoteser Bakgrund / betydelse Pilot studie / prelimin辰ra resultat Inklusions- och exklusionskriterier Utfallsvariabler (outcome) Potentiella confounders (st旦rfaktorer)
  • 9. The devil is in the detail
  • 10. Och om du vill g旦ra dig f旦rst奪dd...
  • 12. Speci鍖ka syften/hypoteser Background/signi鍖cance Pilot study Inclusion and inclusion criteria Outcome measures Potential confounders
  • 13. Speci鍖ka syften I This study aims to examine the prevalence of celiac disease in those thought most at risk: XX (Speci鍖c aim number 1). verambiti旦sa m奪l D奪lig fokusering We aim to study whether the HLA associations seen in European Ingen klar hypotes populations are unaltered by the more heterogenous population of the US. (Speci鍖c aim number 2).
  • 14. Speci鍖ka syften II Speci鍖c aim: 1. To measure the direct health care costs of the IL-1 treatment, as compared with gluten-free diet. 2. XX Syftet f旦ljs av en tydlig The associated hypotheses are: hypotes Hypothesis 1a: In the short term, the IL-1 treatment may result in increased costs compared with gluten-free diet Hypothesis 1b: In the long term, ....
  • 15. Speci鍖c aims/hypothesis Bakgrund/betydelse Pilotstudie Inclusion and inclusion criteria Outcome measures Potential confounders Estimates of attrition rates
  • 16. Bakgrund/betydelse To assess the role of breastfeeding in the etiological pathway of celiac disease is a task of high priority Betona betydelsen We wish to underline that this study can probably only be carried out in Sweden due to the Begr辰nsa bakgrunden existence of the Swedish Personal Identity Number... verdriv inte betydelsen XXXX Therefore, we believe this research av din studie can provide new information on the interplay between early nutrition and in鍖ammation in the young child.
  • 17. Bakgrund/betydelse These studies provide the important background of... Betona betydelsen The current project will build on previous research... Begr辰nsa bakgrunden verdriv inte betydelsen Earlier research is limited by its dependence on...
  • 18. Celiaki Man kan inte g辰rna h辰vda att celiaki 辰r ett st旦rre h辰lsoproblem 辰n cancer.... Men 辰r sjukdomen vanlig / drabbar m奪nga?
  • 19. Speci鍖c aims/hypothesis Background/signi鍖cance Pilotstudie / prelimin辰ra resultat Inclusion and inclusion criteria Outcome measures Potential confounders
  • 20. Inte min f旦rsta ans旦kan Nej Nej Nej Nej Nej Nej Nej Nej Prelimin辰ra resultat Ja!
  • 21. Pilotstudie Relevant erfarenhet Tillr辰ckligt m奪nga deltagare? Testat inklusionen av deltagare?
  • 22. Speci鍖c aims/hypothesis Background/signi鍖cance Pilot study Inklusions- och exklusionskriterier Outcome measures Potential confounders
  • 23. Inklusionskriterier I lder K旦n Studieperiod Geogra鍖skt omr奪de Och gl旦m inte F旦delseland exklusionskriterierna! R旦kare/icke-r旦kare
  • 24. Inklusionskriterier II Goda sk辰l att anv辰nda en viss datak辰lla Risk att studiedeltagarna oftare 辰r Studien b旦r inte vara r旦kare 辰n icke-r旦kare? biased eller icke- representativ! Studiedeltagarna 辰r ovanligt f旦ljsamma? Studiedeltagarna 辰r friskare/ sjukare 辰n genomsnittsinv奪naren? Strikta inklusionskriterier: f辰rre studiedeltagare?
  • 25. Speci鍖c aims/hypothesis Background/signi鍖cance Pilot study Inclusion and exclusion criteria Utfallsvariabler (Outcome) Potential confounders
  • 26. Utfall I Blindad utv辰rderare i randomiserade pr旦vningar Courtesy Wikipedia
  • 27. Utfall II De鍖nition? N辰r har n奪gon + angina pectoris? + Courtesy Wikipedia
  • 28. Utfall III Diabetes No Diabetes Surveillance bias? (旦vervakningsbias) Courtesy Wikipedia
  • 29. Utfall IV Internationella de鍖nitioner? (du kanske vill publicera dina fynd?) 3 ggr / veckan Courtesy Wikipedia
  • 30. Speci鍖c aims/hypothesis Background/signi鍖cance Pilot study Inclusion and exclusion criteria Outcome measures Potentiella confounders /st旦rfaktorer
  • 31. Confounding Inouye and Fiellin 2005 Medicin mot H旦ft fraktur demens lder
  • 32. Sammanfattning Var tydlig Prelimin辰ra resultat De鍖niera utfallet Inklusionskriterier Ta h辰nsyn till confounding