Anti Neoplastic Drugs pharmacology .pptx
- 1. Anti Neoplastic Drugs DR. DANISH RAUF
- 5. Causes
- 11. Cyclophosphamide ? Forms DNA cross-links, resulting in inhibition of DNA synthesis and function ? Use : Breast cancer, ? ovarian cancer non-Hodgkin¡¯s lymphoma ? chronic lymphocytic leukemia ? neuroblastoma
- 12. ? S/E : Nausea and vomiting ? Myelosuppression ? alopecia ? hemorrhagic cyst
- 13. Anti- Metabolites Methotrexate Inhibits DHFR, resulting in inhibition of synthesis of thymidylate, purine nucleotides, serine, and methionine USE : Breast cancer, head and neck cancer, primary CNS lymphoma, non-Hodgkin¡¯s lymphoma, bladder cancer, choriocarcinoma
- 14. ? S/E : ? Myelosuppression, ? immunosuppression, ? hepatotoxicity
- 15. 5 -FU USE : GI cancers, breast cancer, head and neck cancer, hepatocellular cancer
- 17. Vinca alkaloids ? Vincristine ? Interferes with microtubule assembly, resulting in impaired mitosis ? Use : ALL , ? Hodgkin¡¯s and non-Hodgkin¡¯s lymphoma, ? Wilms¡¯ tumor ? neuroblastoma
- 18. ? S/E : Neurotoxicity with peripheral neuropathy paralytic ileus, myelosuppression, alopecia, inappropriate ADH secretion
- 19. Etoposide ? Inhibits topoisomerase II, resulting in DNA damage USE ? Lung cancer, ? non-Hodgkin¡¯s lymphoma ? gastric cancer S/E ? Nausea, vomiting ? Alopecia, ? myelosuppression
- 20. Paclitaxel Interferes with microtubule disassembly, resulting in impaired mitosis USE Breast, lung, ovarian, gastroesophageal, prostate, bladder, and head and neck cancers S /E Nausea, vomiting, hypotension, arrhythmias, hypersensitivity Myelosuppression, peripheral sensory neuropathy
- 21. ANTI TUMOR ANTIBIOTICS ? BLEOMYCIN ? DOXORUBICIN ? MITOMYCIN USE : Lymphoma , Myelomas , Sarcomas , Breast , lung , ovarian and thyroid cancers S/E Nausea Arrhythmias Alopecia Cardiomyopathy
- 22. Tyrosine kinase inhibitors Imatinib Nilotinib Dasatinib Use : CML , GI stromal tumors S/E : Nausea Vomitting Fluid retention with ankle and periorbital edema Mylagias CHF
- 23. Hormonal Antagonists Prednisone Most commonly used glucocorticoid in cancer chemotherapy and is widely used in combination therapy for leukaemia and lymphomas
- 24. ? Tamoxifen Blocks the binding of estrogen to receptors of estrogen sensitive cancer cells in breast tissue Use : Breast Ca S/E : Nausea Vomitting Hot flushes Vaginal bleeding Venous thrombosis
- 25. Flutamide Androgen receptor antagonist used in Prostatic Ca
- 26. Thank You !