Anti retroviral drugs-Integrase inhibitors
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The document discusses several classes of anti-retroviral drugs used to treat HIV, including fusion inhibitors like enfuvirtide which bind to gp41 and prevent viral fusion, CCR5 receptor inhibitors like maraviroc which block the CCR5 co-receptor used by some HIV strains, and integrase inhibitors like raltegravir and elvitegravir which are given orally and active against HIV-1 and 2 with some cross resistance between the two. Integrase inhibitors can be used as part of initial triple drug regimens or as add-on drugs in optimized regimens for treatment-resistant cases.
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Restoring Remission in RRMM: Present and Future of Sequential Immunotherapy W...PVI, PeerView Institute for Medical Education
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Chair, Shaji K. Kumar, MD, and patient Vikki, discuss multiple myeloma in this CME/NCPD/AAPA/IPCE activity titled Restoring Remission in RRMM: Present and Future of Sequential Immunotherapy With GPRC5D-Targeting Options. For the full presentation, downloadable Practice Aids, and complete CME/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/4fYDKkj. CME/NCPD/AAPA/IPCE credit will be available until February 23, 2026.Retinal Disease in Emergency Medicine: Timely Recognition and Referral for Sp...
Retinal Disease in Emergency Medicine: Timely Recognition and Referral for Sp...PVI, PeerView Institute for Medical Education
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Co-Chairs, Robert M. Hughes, DO, and Christina Y. Weng, MD, MBA, prepared useful Practice Aids pertaining to retinal vein occlusion for this CME activity titled Retinal Disease in Emergency Medicine: Timely Recognition and Referral for Specialty Care. For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3NyN81S. CME credit will be available until March 3, 2026.Mastering Mobility- Joints of Lower Limb -Dr. Ahmed Elzainy.pdf
Mastering Mobility- Joints of Lower Limb -Dr. Ahmed Elzainy.pdfInternal medicine department, faculty of Medicine Beni-Suef University Egypt
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Dr. Ahmed Elzainy
Mastering Mobility- Joints of Lower Limb -Dr. Ahmed Elzainy Associate Professor of Anatomy and Embryology - American Fellowship in Medical Education (FAIMER), Philadelphia, USA
Progress Test CoordinatorEnzyme Induction and Inhibition: Mechanisms, Examples, and Clinical Significance
Enzyme Induction and Inhibition: Mechanisms, Examples, and Clinical SignificanceSumeetSharma591398
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This presentation explains the concepts of enzyme induction and enzyme inhibition in drug metabolism. It covers the mechanisms, examples, clinical significance, and factors affecting enzyme activity, with a focus on CYP450 enzymes. Learn how these processes impact drug interactions, efficacy, and toxicity. Essential for pharmacy, pharmacology, and medical students.Strategies for Promoting Innovation in Healthcare Like Akiva Greenfield.pdf
Strategies for Promoting Innovation in Healthcare Like Akiva Greenfield.pdfakivagreenfieldus
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Healthcare innovation has been greatly aided by leaders like Akiva Greenfield, CEO of Nexus, particularly in fields like operational efficiency, revenue cycle management (RCM), and client engagement. In order to ensure both operational success and better patient experiences, Akiva's approach combines technological advancements with an emphasis on improving the human side of healthcare.
Addressing Unmet Needs for Better Outcomes in DLBCL: Leveraging Prognostic As...
Addressing Unmet Needs for Better Outcomes in DLBCL: Leveraging Prognostic As...PVI, PeerView Institute for Medical Education
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Advancements in IgA Nephropathy: Discovering the Potential of Complement Path...
Advancements in IgA Nephropathy: Discovering the Potential of Complement Path...PVI, PeerView Institute for Medical Education
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Restoring Remission in RRMM: Present and Future of Sequential Immunotherapy W...
Restoring Remission in RRMM: Present and Future of Sequential Immunotherapy W...PVI, PeerView Institute for Medical Education
油
Retinal Disease in Emergency Medicine: Timely Recognition and Referral for Sp...
Retinal Disease in Emergency Medicine: Timely Recognition and Referral for Sp...PVI, PeerView Institute for Medical Education
油
Mastering Mobility- Joints of Lower Limb -Dr. Ahmed Elzainy.pdf
Mastering Mobility- Joints of Lower Limb -Dr. Ahmed Elzainy.pdfInternal medicine department, faculty of Medicine Beni-Suef University Egypt
油
Anti retroviral drugs-Integrase inhibitors
- 1. Anti retroviral drugs Utkarsh Jain 16093
- 4. Enfurvirtide Binds to gp41, prevents conformational change Not active against HIV-2 No cross resistance with other classes of ARV Administered s/c twice daily Given as add on drug to an optimised regimen in resistant cases Injections are painful and cause local irritation and nodules/cysts
- 6. Maraviroc Blocks CCR5 co-receptor No effect on CXCR4 receptor tropic strains Also used as an add on drug Orally administered No cross resistance with any other ARV drug Increased risk of infection/malignancy Metabolised by CYP450
- 9. Integrase Inhibitors Raltegravir Elvitegravir Dolutegravir
- 10. Raltegravir Given orally Active against both HIV-1 and 2 No cross resistance to other classes of ARV but cross resistance with elvitegravir is present Given as add on drug in an optimised regimen Can also be given as a component of initial triple drug regimen( 2NRTI + 1NNRTI/Integrase inhibitor) in untreated patients Generally well tolerated Serious adverse effects Muscle pain and rhabdomyolysis