Antiinflammatory agents
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This document discusses inflammation, non-steroidal anti-inflammatory drugs (NSAIDs), and ibuprofen specifically. It notes that inflammation is a normal process initiated by stimuli like injury to facilitate tissue repair. NSAIDs are commonly prescribed and over-the-counter drugs that work by decreasing prostaglandin production through inhibiting cyclooxygenase enzymes. Ibuprofen is one of the most frequently used NSAIDs, introduced over-the-counter in 1985, and used for fever reduction and pain relief in both adults and children due to its longer duration than acetaminophen.
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This document discusses NSAIDs (nonsteroidal anti-inflammatory drugs) used for dental pain relief. It begins by introducing NSAIDs and their analgesic, antipyretic, and anti-inflammatory properties. NSAIDs are then classified based on their chemical structure and clinical applications. The mechanisms of action for their analgesic, antipyretic and anti-inflammatory effects are described. Common adverse effects are also outlined. Specific NSAIDs discussed in more detail include aspirin and ibuprofen, focusing on their pharmacological actions, uses, dosages and adverse effects.Non narcotic analgesics .pptx
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This document provides an overview of non-narcotic analgesics, also known as nonsteroidal anti-inflammatory drugs (NSAIDs). It discusses the mechanisms of action and pharmacological properties of various classes of NSAIDs, including salicylates, para-aminophenol derivatives, propionic acid derivatives, acetic acid derivatives, pyrazolone derivatives, and oxicam derivatives. The document also covers preferential and selective COX-2 inhibitors as well as factors to consider when choosing an appropriate NSAID for different pain conditions.Anti rheumatic drug ( NSAIDs and DMARDs )
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This document provides an overview of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). It discusses the history and classification of NSAIDs, including non-selective COX inhibitors, preferential COX-2 inhibitors, and selective COX-2 inhibitors. Specific NSAIDs are described in more detail, including aspirin, paracetamol, diclofenac, indomethacin, ketorolac, etodolac, naproxen, ibuprofen, piroxicam, meloxicam, celecoxib, and etoricoxib. Their mechanisms of action, pharmacokinetics, therapeutic uses, and adverse effects are summarized for each. The document aimsParacetamol
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The document discusses fever and its treatment with antipyretics. It compares paracetamol (Dolonerv) to other NSAIDs like ibuprofen and nimesulide. Paracetamol is considered the first-line treatment for fever due to its excellent safety profile. It has few drug interactions and side effects are rare at recommended doses. Overdose can cause hepatotoxicity but an antidote is available within 10 hours. Other NSAIDs have greater risks of side effects like gastrointestinal bleeding and kidney damage.Non narcotic analgesics
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This document provides information on non-narcotic analgesics (NSAIDs) that have analgesic, antipyretic, and anti-inflammatory properties. It discusses the inflammatory process and pain pathway, how NSAIDs work by inhibiting prostaglandin synthesis via inhibition of cyclooxygenase enzymes, and the classification of various NSAIDs including aspirin, ibuprofen, naproxen, indomethacin, and others. It covers the pharmacological actions, pharmacokinetics, uses, and adverse effects of different NSAID classes.tablet NSAID NSAID NSAID NSAID NSAID.pptx
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The document provides a detailed overview of non-steroidal anti-inflammatory drugs (NSAIDs), their classifications, mechanisms of action, pharmacokinetics, clinical uses, and potential side effects. It covers various types of NSAIDs including salicylates, propionic acid derivatives, and COX-2 inhibitors, along with the specifics of aspirin, ibuprofen, and other notable NSAIDs. Additionally, it discusses the potential adverse effects, contraindications, and the treatment of overdoses associated with these medications.Non steroidal anti inflammatory drugs(NSAIDs) presentation
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The document provides an extensive overview of non-steroidal anti-inflammatory drugs (NSAIDs), detailing their functions, classifications, therapeutic uses, and effects on the body. It summarizes the mechanisms of action of different NSAIDs, the roles of cyclooxygenase enzymes, and highlights the potential side effects and contraindications associated with their use. Additionally, it covers specific conditions for which NSAIDs are effective and the precautions necessary when using these drugs with other medications.NSAID , GOUT.pdf
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This document contains information about various medications used to treat pain and inflammation. It discusses NSAIDs like aspirin, ibuprofen, naproxen, celecoxib and indomethacin. It also covers opioids like morphine, codeine, fentanyl and methadone. Additional topics include paracetamol, allopurinol for gout, drug interactions and side effects of these medications.13.-Non-steroidal-anti-inflammatory-drugs.pptx
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NSAIDs have analgesic, antipyretic and anti-inflammatory properties. They work by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin production. NSAIDs are classified as nonselective COX inhibitors like aspirin, preferential COX-2 inhibitors like nimesulide, or selective COX-2 inhibitors like celecoxib. Common adverse effects include gastrointestinal irritation. NSAIDs are used to treat pain, fever, and inflammation conditions like arthritis.Dr.Reena J Deshmukh
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This document discusses antipyretic and analgesic drugs. It describes antipyretic drugs as those that reduce fever through inhibiting prostaglandin production. The two main types are nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and acetaminophen. NSAIDs can cause stomach irritation while acetaminophen risks liver damage at high doses. Analgesic drugs relieve pain and include non-opioid analgesics and opioids prescribed for severe pain. Both antipyretic and analgesic drugs are important for managing fever and pain.Traditional immunosuppressants
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The document discusses the role of non-steroidal anti-inflammatory drugs (NSAIDs) in periodontics, detailing their classification, mechanism of action, benefits, and adverse effects. It covers the historical context of NSAIDs, including significant drugs such as aspirin and their therapeutic applications, while also outlining potential risks and drug interactions. The document provides an in-depth overview of the pharmacological, gastrointestinal, renal, and cardiovascular effects of NSAIDs, emphasizing their relevance in dental care.Dr tarek NSAIDs
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NSAIDs are a class of drugs that relieve pain, fever, and inflammation by inhibiting cyclooxygenase enzymes. There are various types of NSAIDs classified by their chemical structure. All NSAIDs work by blocking prostaglandin production, but they differ in their selectivity for COX-1 vs COX-2 enzymes. Common adverse effects include gastrointestinal irritation and bleeding, as well as renal impairment. NSAIDs are commonly used to treat pain, fever, and inflammatory conditions like arthritis.Cox 1 and cox 2 inhibitirs
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The document provides a comprehensive overview of non-steroidal anti-inflammatory drugs (NSAIDs), including their pharmacological properties, mechanisms of action, and historical development. It discusses various types of NSAIDs, their therapeutic effects on pain, fever, inflammation, and specific conditions like dysmenorrhea and cardiovascular events. Additionally, it addresses potential side effects and the role of NSAIDs in gastrointestinal and renal health.ROLE OF NON STEROIDAL ANTI- INFLAMMATORY DRUGS IN PERIODONTICS.pptx
ROLE OF NON STEROIDAL ANTI- INFLAMMATORY DRUGS IN PERIODONTICS.pptxRama Dental College Hospital and Research Center
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Antiinflammatory agents
- 2. INFLAMMATION PROCESS A normal, beneficial process that begins immediately after injury to facilitate repair and return the tissue to normal function and Initiated by stimulus including physical trauma, radiation, chemicals, heat, infection, and hypersensitivity infection, Causes the release of chemical mediators.
- 3. NON STEROIDAL ANTIINFLAMMATORY DRUGS Most frequently prescribed and frequently used OTC drugs Major mechanism of action is to decrease PG production by inhibiting one decrease or both of the cyclo oxygenase isoforms (COX- 1, COX-2) COX-2 is enhanced in response to pain and inflammation so NSAIDs primarily inhibit this isoform rather than both COX -1 and COX 1 and COX-2.
- 4. Ibuprofen Advil, Motrin, Nuprin Most frequently used NSAID Introduced to the OTC market in 1985, it is available in 200 to 800 mg tablets by prescription, and 200 mg tablets OTC Frequently used as an antipyretic in adults and children, as its longer duration of action makes it a popular alternative to acetaminophen
- 6. Peak plasma levels are achieved within 15 to 30 minutes of ingestion Rapid onset of action can be quite beneficial for quick relief of pain Half-life of about 2 hours, it must be taken every 6 to 8 hours to maintain effect An anti-inflammatory regimen requires 2400 3200 mg daily
- 7. Taken in three separate doses, allowing it to be taken at meal times, lessening the likelihood of gastric irritation. Sufficient analgesia should be achieved by daily dosages of less than 2400 mg per day. Approximately 10 percent to 15 percent of individuals must discontinue use secondary to gastrointestinal symptoms