APLA SYNDROME
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This document presents several case studies demonstrating the myriad presentations of Anti-Phospholipid Antibody Syndrome (APLA Syndrome). The cases include a woman who developed gangrene of her fingers and was treated with low molecular weight heparin; a woman who had recurrent abortions and delivered with anticoagulation treatment; and a woman who developed deep vein thrombosis and was found to have various positive autoantibodies. The document demonstrates that APLA Syndrome can present with issues like thrombocytopenia, Budd-Chiari syndrome, pancreatitis, and cerebral sinus thrombosis.
APLA SYNDROME
- 1. APLA SYNDROME - Anti Phospholipid Antibody Syndrome Myriad Presentation Dr.Anita Dr.K.S.V.Chalam,Dr.A.Lalitha,Dr.A.P.Naveen Kumar,Dr.D.V.N.Sharma, Dr. M.K.Tripathy
- 3. • Polyarthritis and rash • Gangrene of tips of fingers • Treated with LMWH and then acitrom • Recovered completely • ANA , DsDNA , Anti Cardiolipin positive • On follow up
- 4. • 28 yr. female • Recurrent abortions • Anti cardiolipin antibodies positive • Started on anticoagulants • Delivered a female baby with LMWH
- 5. ACA SYNDROME
- 6. • 34 yr. female • Polyarthritis and skin rash • Developed swelling of leg • Doppler showed DVT • ANA,DsDNA,Smith and Anti cardiolipin Ab. positive
- 8. • Presented with septicemia and MODS • Recovered completely except for thrombocytopenia • ANA positive – treated with steroids • After 1 yr. developed swelling of abdomen • U/S s/o Budd Chiari • Investigations confirmed APLA
- 10. • 12 yr. girl • Recurrent abdominal pain • Confirmed as pancreatitis • Later symptoms of rash and arthritis • Investigations for SLE and APLA positive • On immunomodulants and acitrom • Developed CNS lupus and recovered
- 12. • Presented with convulsions • MRI brain – large bleed • Thrombocytopenia • MR Venogram – Sup. Saggital sinus thrombosis • APLA workup positive