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Application of nmr id 20131207058 presentation 21 11-2017 - copy - copy

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subro Biswas

This presentation discusses the application of Nuclear Magnetic Resonance (NMR) spectroscopy. NMR is an analytical technique used to determine the content, purity, and molecular structure of samples. It has various applications in fields like medicine, materials science, pharmaceutical research, and structural biology. In medicine, NMR is used for imaging tissues and organs in the brain, abdomen, kidneys, pelvis, heart, and musculoskeletal system. It is also used to study protein folding, ionization states, hydration, and metabolite analysis. In pharmaceutical research, NMR aids in structural determination, studying protein-ligand interactions, and structure-activity relationships, supporting drug discovery.

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Presentation Topic: Application of Nuclear Magnetic Resonance (NMR) Course Title: Instrumental Methods of Chemical Analysis Course Code: ACCE 360 Applied Chemistry & Chemical Engineering Presentation Date: 21-11-2017 Md. Subrata Kumar Biswas ID -20131207058 Dept. of ACCE
Definition: Nuclear Magnetic Resonance is a branch of spectroscopy that deals with the phenomenon found in assemblies of large number of nuclei of atoms that possess both magnetic moments and angular momentum is subjected to external magnetic field. Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure. Nuclear Magnetic Resonance (NMR)
Introduction Now a days , NMR has become a sophisticated and powerful analytical technology that has found a variety of applications in many disciplines of scientific research, medicine, and various industries. Modern NMR spectroscopy has been emphasizing the application in bimolecular systems and plays an important role in structural biology.
APPLICATIONS OF NMR IN MEDICINE BRAIN Distinguishing gray matter & white matter Imaging posterior fossae, brain stem, spinal cord Detect demyelinating lesions, tumors, hemorrhages, infarctions ABDOMEN oMetabolic liver disease oMeasures liver iron over load in hemochromatosis oFocal areas of inflammation in chronic active hepatisis.
KIDNEYS o Distinguishing renal cortex & medulla o To evaluate transplanted kidney PELVIS o Differentiates between Benign prostatic hyperplasia & prostatic carcinoma o Detects bladder tumours HEART o Tomographic images of heart muscle, chambers, valvular structures o ECHO-PLANAR TECHNIQUE o Discrimination between infarcted, ischemic & normal myocardium APPLICATIONS OF NMR
MUSCULO SKELETAL SYSTEM Demonstrates Osteo myelitis, tumor metastasis in vertebral bodies & pelvic bones Images of muscles, tendons, ligaments BLOOD VESSELS & FLOW Atherosclerotic vascular disease Assess blood flow in major vessels. INVIVO SPECTROSCOPY Chemical shift phenomenon Diagnosis of rare disease to inborn errors-Mc Ardles syndrome INVIVO Analysis of Bone flouride content. APPLICATIONS OF NMR
Protein folding: The most powerful tool for determining the residual structures of unfolded proteins and the structures of folding intermediates. Ionization state: The most powerful tool for determining the chemical properties of functional groups in biomacromolecules, such as the ionization states of ionizable groups at the active sites of enzymes. Protein hydration: A power tool for the detection of interior water and its interaction with biomacromolecules. APPLICATIONS OF NMR
Material science: A powerful tool in the research of polymer chemistry and physics. Hydrogen bonding: A unique technique for the DIRECT detection of hydrogen bonding interactions. Metabolite analysis: A very powerful technology for metabolite analysis. APPLICATIONS OF NMR
APPLICATIONS OF NMR IN PHARMACEUTICAL RESEARCH Leading technology for 3-D structure determination of bio- macromolecules Studying protein structure Structure-activity relationship(SAR) by NMR Novel lead compounds Chemical shift mapping Structural information on the binding modes and site positions Molecular dynamics, conformational analysis SHAPES NMR SOLVE
Structural genomics Identifying gene products in disease Targets of drug design. Drug Discovery Research: NMR has become the single most powerful form of spectroscopy in both chemistry and structural biology. The recent technical advances have remarkably increased the range of applications for NMR in the study of proteinligand interactions. These form the basis for its most exciting uses in the drug discovery process, which range from the simple identification of whether a compound (or a component of a mixture) binds to a given protein, through to the determination of the full three-dimensional structure of the complex, with all the information this yields for structure-based drug design .
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Application of nmr id 20131207058 presentation 21 11-2017 - copy - copy

  • 2. Presentation Topic: Application of Nuclear Magnetic Resonance (NMR) Course Title: Instrumental Methods of Chemical Analysis Course Code: ACCE 360 Applied Chemistry & Chemical Engineering Presentation Date: 21-11-2017 Md. Subrata Kumar Biswas ID -20131207058 Dept. of ACCE
  • 3. Definition: Nuclear Magnetic Resonance is a branch of spectroscopy that deals with the phenomenon found in assemblies of large number of nuclei of atoms that possess both magnetic moments and angular momentum is subjected to external magnetic field. Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and reserach for determining the content and purity of a sample as well as its molecular structure. Nuclear Magnetic Resonance (NMR)
  • 4. Introduction Now a days , NMR has become a sophisticated and powerful analytical technology that has found a variety of applications in many disciplines of scientific research, medicine, and various industries. Modern NMR spectroscopy has been emphasizing the application in bimolecular systems and plays an important role in structural biology.
  • 5. APPLICATIONS OF NMR IN MEDICINE BRAIN Distinguishing gray matter & white matter Imaging posterior fossae, brain stem, spinal cord Detect demyelinating lesions, tumors, hemorrhages, infarctions ABDOMEN oMetabolic liver disease oMeasures liver iron over load in hemochromatosis oFocal areas of inflammation in chronic active hepatisis.
  • 6. KIDNEYS o Distinguishing renal cortex & medulla o To evaluate transplanted kidney PELVIS o Differentiates between Benign prostatic hyperplasia & prostatic carcinoma o Detects bladder tumours HEART o Tomographic images of heart muscle, chambers, valvular structures o ECHO-PLANAR TECHNIQUE o Discrimination between infarcted, ischemic & normal myocardium APPLICATIONS OF NMR
  • 7. MUSCULO SKELETAL SYSTEM Demonstrates Osteo myelitis, tumor metastasis in vertebral bodies & pelvic bones Images of muscles, tendons, ligaments BLOOD VESSELS & FLOW Atherosclerotic vascular disease Assess blood flow in major vessels. INVIVO SPECTROSCOPY Chemical shift phenomenon Diagnosis of rare disease to inborn errors-Mc Ardles syndrome INVIVO Analysis of Bone flouride content. APPLICATIONS OF NMR
  • 8. Protein folding: The most powerful tool for determining the residual structures of unfolded proteins and the structures of folding intermediates. Ionization state: The most powerful tool for determining the chemical properties of functional groups in biomacromolecules, such as the ionization states of ionizable groups at the active sites of enzymes. Protein hydration: A power tool for the detection of interior water and its interaction with biomacromolecules. APPLICATIONS OF NMR
  • 9. Material science: A powerful tool in the research of polymer chemistry and physics. Hydrogen bonding: A unique technique for the DIRECT detection of hydrogen bonding interactions. Metabolite analysis: A very powerful technology for metabolite analysis. APPLICATIONS OF NMR
  • 10. APPLICATIONS OF NMR IN PHARMACEUTICAL RESEARCH Leading technology for 3-D structure determination of bio- macromolecules Studying protein structure Structure-activity relationship(SAR) by NMR Novel lead compounds Chemical shift mapping Structural information on the binding modes and site positions Molecular dynamics, conformational analysis SHAPES NMR SOLVE
  • 11. Structural genomics Identifying gene products in disease Targets of drug design. Drug Discovery Research: NMR has become the single most powerful form of spectroscopy in both chemistry and structural biology. The recent technical advances have remarkably increased the range of applications for NMR in the study of proteinligand interactions. These form the basis for its most exciting uses in the drug discovery process, which range from the simple identification of whether a compound (or a component of a mixture) binds to a given protein, through to the determination of the full three-dimensional structure of the complex, with all the information this yields for structure-based drug design .