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Arginine metabolism by aslam matania

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Aslam Matania

Arginine is a semiessential amino acid that is synthesized endogenously in the liver and kidney cortex. It plays an important role in the urea cycle, where it is both synthesized and hydrolyzed. Arginine is also involved in the citrulline-nitric oxide cycle, where it is converted by nitric oxide synthase enzymes into nitric oxide, an important signaling molecule. Disruptions to arginine metabolism can occur due to deficiencies in its synthesizing or metabolizing enzymes and can result in medical conditions like hyperargininemia or hypoargininemia.

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ARGININE METABOLISM BY ASLAM MATANIA GROUP-3 FACULTY OF MEDICINE TSMU
WHAT IS ARGININE? Arginine is an 留-amino acid In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.
STRUCTURE The amino acid side-chain of arginine consists of a 3-carbon aliphatic straight chain, the distal end of which is capped by a complex guanidinium group
METABOLISM The two main sites of endogenous arginine synthesis are LIVER(where arginine is both synthesis and hydrolyzed within urea cycle)and KIDNEY CORTEX where most of the synthesized L-arginine is released into blood and transported throughout body
Cytosolic Enzyme required are- argininosuccinate synthetase(ASS) andargininosuccinate lyase(ASL) It require 2 ATP
synthesis of arginine occurs in intestinalrenal axis which producecitrulline fromglutamineandglutama te, kidney, which extract
Arginine metabolism by aslam matania
ARGININE PATHWAY
CITRULLINE AND ARGININE CYCLE
The enzyme nitric oxide synthase (three isoenzymes) cleaves the nitrogen from the guanidino group of arginine to form NO. Requires NADPH, FMN, FAD, heme & tetrahydrobiopterin(BH4)
Arginine metabolism by aslam matania
AGMATINE Agmatine: It is a derivative of arginine produced in the brain by decarboxylation. Agmatine possesses antihypertensive properties.
Abnormalities Except arginase other enzyme def. in urea cycle distrubs arginine level in the body. Hyperargininemia inborn error in arginine metabolism due to a defect in the enzyme arginase. Hypoargininemia premature occurs before the burst of cortisol production that occurs late in preg. Cortisol is req for activation of arginine synthetic enzymes Remedy + of cortisol to infant(premature) may improve growth and survival rate
Arginine metabolism by aslam matania

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Arginine metabolism by aslam matania

  • 2. WHAT IS ARGININE? Arginine is an 留-amino acid In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.
  • 3. STRUCTURE The amino acid side-chain of arginine consists of a 3-carbon aliphatic straight chain, the distal end of which is capped by a complex guanidinium group
  • 4. METABOLISM The two main sites of endogenous arginine synthesis are LIVER(where arginine is both synthesis and hydrolyzed within urea cycle)and KIDNEY CORTEX where most of the synthesized L-arginine is released into blood and transported throughout body
  • 5. Cytosolic Enzyme required are- argininosuccinate synthetase(ASS) andargininosuccinate lyase(ASL) It require 2 ATP
  • 6. synthesis of arginine occurs in intestinalrenal axis which producecitrulline fromglutamineandglutama te, kidney, which extract
  • 10. The enzyme nitric oxide synthase (three isoenzymes) cleaves the nitrogen from the guanidino group of arginine to form NO. Requires NADPH, FMN, FAD, heme & tetrahydrobiopterin(BH4)
  • 12. AGMATINE Agmatine: It is a derivative of arginine produced in the brain by decarboxylation. Agmatine possesses antihypertensive properties.
  • 13. Abnormalities Except arginase other enzyme def. in urea cycle distrubs arginine level in the body. Hyperargininemia inborn error in arginine metabolism due to a defect in the enzyme arginase. Hypoargininemia premature occurs before the burst of cortisol production that occurs late in preg. Cortisol is req for activation of arginine synthetic enzymes Remedy + of cortisol to infant(premature) may improve growth and survival rate