The document discusses the discovery of the arNOX enzyme, an internal free radical generator in skin cells that increases with age and contributes to skin aging. Studies found that arNOX levels correlate with chronological age and that high arNOX levels are associated with appearing 7 years older, while low levels are associated with appearing 7 years younger. Nu Skin scientists developed an arNOX inhibitor ingredient that blocks arNOX enzyme activity and free radical production in experiments, suggesting a potential therapy to slow skin aging by targeting this source.
2. HAVE YOU EVER WONDERED
WHY SOME PEOPLE
LOOK YOUNGEROR OLDER
THAN THEIR ACTUAL AGE?
NU SKIN HAS THE ANSWER.
IN YOUR YOUTHFUL TWENTIES YOUR SKIN PRODUCES ABUNDANT
amounts of collagen and elastinthe skins structural proteins responsible
for 鍖rm, smooth, resilient skin. But as you age, continuous exposure to
free radicals in鍖icts damage on these proteins and reduces their production
in the body, causing the skin to wrinkle and sag.
Most of us know its important to protect our skin from the dangerous,
skin damaging effects of the sun and environment, and we use the latest
skin care technologies to try to repair and prevent signs of aging. So why
do some of us still appear to age faster than we think we should?
In a revolutionary skin care breakthrough, Nu Skin has unlocked the science
behind the secret of why some people seem to look younger longer.
4. REVOLUTIONARY DISCOVERY
THE arNOX ENZYME
SKIN DAMAGING
FREE RADICALS
arNOX ENZYME
NEW RESEARCH BY DRS. JAMES AND DOROTHY MORR HAS IDENTIFIED
a major, previously undiscovered source of aging within each of us: an internal free
radical generator in the epidermisthe arNOX enzyme. And our genes control its
activity, which increases as we age. Present on the surface of our cells, this invisible
enemy is capable of generating skin damaging free radicals around the clock that
can destroy collagen and elastin. The result? Looking years older than you already are.
5. SERUM arNOX CORRELATES WITH AGE
SUPEROXIDE PRODUCTION (arNOX ACTIVITY) MEASURED AS
FERRICYTOCHROME C REDUCTION, NMOLES/MIN/ML
DURING A STUDY CONDUCTED AT PURDUE UNIVERSITY, SCIENTISTS
discovered that arNOX levels correlate with chronological age and that arNOX
activity starts to increase during the aging years, beginning sometime during
the mid-thirties. Scientists also concluded that a persons arNOX activity is not
triggered by sun exposure, providing further evidence that increased arNOX
activity is an identi鍖ed source of biological aging.
UNLIKE THE SUN, YOU CAN'T HIDE FROM arNOX. BUT NOW YOU CAN SLOW ITS
6. arNOX=LOOKING YOUNGER OR OLDER
IN A STUDY CONDUCTED AT STANFORD UNIVERSITY, RESULTS INDICATED
that people with high levels of this aging enzyme can appear older than their
biological age, while those with low levels can appear younger.
HIGH arNOX LEVEL +18 STANFORD
+16 STUDY SHOWS
+14 Individuals with high
7
+12
levels of arNOX appear
AVERAGE OF YEARS OLDER +10
+8 to be an average of seven
ACTUAL AGE IN YEARS
+6 years older than their
+4
arNOX LEVEL
+2 actual age.
7
-2 Individuals with low
AVERAGE OF YEARS YOUNGER -4
-6
-8
arNOX levels are clinically
graded to look an
-10 average of seven years
-12
-14 younger than their actual
-16 chronological age.
-18
LOW arNOX LEVEL
EVIDENCE OF arNOX IN THE SKIN PROVIDES FURTHER INSIGHTS INTO POTENTIALLY R
because its activity correlates with the ages when people begin to see their skin lose its elas
wrinkles. If we can develop innovative ways to inhibit arNOX activity and prevent the produc
sides of the equationcorrecting free radical damage from external sources, while at the sam
HELEN KNAGGS, PH.D., VICE PRESIDENT OF NU SKIN GLOBAL RESEARCH AND DEVELOPMENT
S DAMAGING EFFECTS. FOR MORE INFORMATION, VISIT WWW.AGELOC.COM.
7. SLOW THE SOURCE
NU SKIN SCIENTISTS TESTED INGREDIENTS THAT WOULD HELP PREVENT
the expression of free radicals associated with the arNOX enzyme. This
prevention may help us develop ways to slow the signs of aging that come
from accelerated free radical production.
APPLIED arNOX INHIBITOR INGREDIENT
This experiment shows
arNOX Activity
how an in vitro ar NOX
inhibitor can block ar NOX
enzyme activity and
production of damaging
free radicals.
Time
arNOX ACTIVITY measured in vitro through FERRICYTOCHROME C REDUCTION
nmoles/min/1.5 mg epidermis
Y REVOLUTIONARY THERAPIES FOR SKIN CARE, PARTICULARLY
lasticity and 鍖rmness, and notice more discoloration and lines and
duction of free radicals in the 鍖rst place, then we can address both
ame time preventing free radical production from internal sources.
8. 息 2009 Nu Skin Enterprises, Inc.
75 West Center Street, Provo, UT 84601
1-800-487-1000 www.nuskin.com
01007073 US 5PK
息 2009 Nu Skin Canada, Inc.
3350 Ridgeway Drive, Unit #1
Mississauga, Ontario, Canada, L5L 5Z9
1-800-877-6100 www.nuskin.com/canada
02007073 CA 5PK