ATRACURIUM BESYLATE
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Atracurium besylate is a non-depolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgery or mechanical ventilation. It lacks significant cardiovascular effects and does not require kidney function for elimination, offering advantages over other non-depolarizing agents. Atracurium besylate works by competitively binding to cholinergic receptor sites at the motor end-plate, antagonizing the action of acetylcholine, and this antagonism can be reversed by acetylcholinesterase inhibitors like neostigmine. It has a short duration of action and half-life of 20 minutes.
ATRACURIUM BESYLATE
- 1. ATRACURIUM BESYLATE GENERIC NAME: Atracuriumbesylate BRANDNAME: Acuron,Atrelax DESCRIPTION:A non-depolarizingneuromuscularblockingagentwithshortdurationof action.Itslack of significantcardiovasculareffectsanditslackof dependence ongood kidneyfunctionforelimination provide clinical advantageoveralternatenon-depolarizingneuromuscularblockingagents. CATEGORY: Nondepolarizingmuscle relaxant. CONTENT:Inj:per ml atracuriumbesylate:10mg INDICATION:AtracuriumBesylate Injectionis indicated,asanadjunctto general anesthesia,tofacilitate endotracheal intubationandtoprovide skeletal muscle relaxationduringsurgeryormechanical ventilation. PREGNANCY:Riskcannotbe ruledout LACTATION:cautionadvisedoreffectsundetermined PRECAUTION:shouldbe administeredonlywithadequategeneral anesthesia andunderthe close supervisionof anesthesist CONTRAINDICATION:Hypersensitivity INTERACTION:Anticholinesterases,thiazide diuretics ADVERSEEFFECTS: Skinflush. PHARMACODYNAMICS:Atracuriumantagonizesthe neurotransmitteractionof acetylcholinebybinding competitivelywithcholinergicreceptorsitesonthe motorend-plate.Thisantagonismisinhibited,and neuromuscularblockreversed,byacetylcholinesterase inhibitorssuch asneostigmine,edrophonium, and pyridostigmine HALF LIFE: 20 minutes