Autoimmune disorder systemic lupus erythematosis ppt
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R Sharmila prepared this document about systemic lupus erythematosus (SLE). SLE is an autoimmune disorder where the immune system attacks its own tissues, causing inflammation in connective tissues like skin and joints. Common symptoms include fatigue, joint pain and swelling, rashes, and blood disorders. The causes are not fully known but may involve genetic and environmental factors like UV exposure and stress. The condition results from a defect where the body produces antibodies against its own proteins, triggering inflammation. Treatment focuses on relieving symptoms and involves medications like anti-inflammatories, steroids, and stress reduction.
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Systemic means affects multiple organs.
Lupus is the Latin word for wolf meaning disease affecting skin where the skin lesions look like wolf bite.
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Systemic Lupus Erythematosus or SLE, sometimes also called just lupus is a disease that’s systemic and affects a wide variety of organs, but notably often causes red lesions on the skin.
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Individuals with SLE are noted with the production of antibodies and inflammatory responses that are mistakenly directed at their own tissue.
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Autoimmune disorder systemic lupus erythematosis ppt
- 1. Prepared by, R Sharmila Prepared by, R Sharmila
- 2. GENERAL DESCRIPTION:  It is a chronic disease cause inflammation in connective tissues.  Generally connective tissues gives structure and flexibility.  Symptoms may vary according to the individual.  It is a type of autoimmune disorder.  Most affected individual have joint pain.  Skin problems are common in SLE.
- 3.  Characteristic feature is across the cheeks and the nose, called "Butterfly rashes".  Rash does not itch.  Tiny red spots appear on the skin called as Petechiae, it leads to bleeding under the skin.  It develop kidney problem too.  It affects women more than men.
- 4. SYMPTOMS: ï‚ž Fatigue ï‚ž Joint pain ï‚ž Joint swelling ï‚ž Rashes on the skin ï‚ž Aneamia ï‚ž Blood clot
- 5. CAUSES: ï‚ž Exposure to UV rays ï‚ž Stress ï‚ž Certain medication induce SLE
- 6. PATHOGENESIS:  Body produces own antibodies against self protein.  It is a Type III Hypersensitivity.  T cell regulate B cell responses and infiltrate target tissues, have defects in signalling, adhesion, co – stimulation, gene transcription and alternative splicing.  Cytokine B cell stimulator (BLys), IL-6, IL-17, IL- 18, type I interferons and TNF α are involved in the inflammation process.  Apoptosis is increased.
- 7. DIAGNOSIS: ï‚ž Butterfly rashes. ï‚ž Mucous membrane ulcer in mouth or nose. ï‚ž Blood tests
- 8. TREATMENT: • It cannot be cured by medication • Treatment can vary based on the symptoms. • Anti inflammatory medication for joint pain • Creams for rashes. • Corticosterois • Minimizing the stress